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Brain, respiration and cardiac causalities in anaesthesia

Objective

Recent developments in the analysis of synchronization and directionality of couplings for nonlinear and chaotic oscillators will be applied to study the complex interactions between brain waves and cardio-respiratory oscillations during anaesthesia. Pre liminary studies have shown that marked changes occur in the inter-oscillator interactions during anaesthesia. These could form a new bases for measurement of anaesthesia. An interdisciplinary consortium of scientist will carry out and analyse experiment s on humans and rats. The work will involve (i) further development of methods for analyses of complex interactions, (ii) measurements and data collection, (iii) time series analysis, (iv) mathematical modelling of interactions between coupled oscillato rs, and (v) neurological, physiological and clinical interpretation of mechanisms of inter-oscillator couplings during anaesthesia and consciousness. Causal relationships between the oscillatory processes will be evaluated for various stages of anaesthesi a and consciousness. Protocols will be prepared for a larger scale study that will follow and will aim at standardising the measures for depth of anaesthesia based on inter-oscillators couplings. The tools developed during this research programme will be directly applicable to anaesthesiology, cardiovascular studies, neurology and physiology, but will also be useful for reviling complex interactions quite generally, e.g. in meteorology, geology, sociology and economics.

Coordinator

LANCASTER UNIVERSITY

Address

Bailrigg
Lancaster

United Kingdom

Administrative Contact

Participants (6)

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ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

MORECAMBE BAY HOSPITALS NHS TRUST

United Kingdom

ULLEVAEL UNIVERSITY HOSPITAL

Norway

UNIVERSITAET POTSDAM

Germany

UNIVERZA V LJUBLJANI

Slovenia

USTAV INFORMATIKY AVCR

Czechia

Project information

Grant agreement ID: 517133

  • Start date

    1 June 2005

  • End date

    28 February 2009

Funded under:

FP6-POLICIES

  • Overall budget:

    € 1 477 457

  • EU contribution

    € 1 417 200

Coordinated by:

LANCASTER UNIVERSITY

United Kingdom