The rapid growth in the prevalence of obesity and associated co-morbidities, in particular the rise in childhoodobesity across Europe are major global health concerns. Susceptibility to obesity is determined largely bygenetic factors but the current epidemic is significantly influenced by lifestyle factors. Given our geneticbackground it is largely infeasible to self-regulate food intake in the current environment. Innovative scientificapproaches to the problem are needed. DiOGenes aims to respond by including all disciplines and stakeholderswho can contribute to a better understanding of the disease and its alleviation by dietary means. DiOGenes'primary dietary focus is on macronutrients that will facilitate a healthy weight, specifically the role of thecarbohydrate Glycmie Index and of a high protein content in enhancing satiety. To examine critically the dietaryimpact, an 8-country, long-term randomised, parallel dietary intervention study on whole families will take place.To identify gene-nutrient interactions linked with changes in body weight and waist circumference, DiOGenes isuniquely positioned trough access to long-term prospective cohorts across Europe. Large-scale longitudinalanalysis of variation in candidate genes, plus approaches such as gene expression in fat tissue and plasmapeptidomics, will search for genetic biomarkers, ultimately enabling prediction of individuals' responses tonutrients in terms of weight change, in turn leading to diet-based treatment. The epidemiological and interventionstudies will be complemented by innovative analysis of the psychological/behavioural responses of subjects.Food technology studies will seek to develop food combining high consumer liking/preference with enhancedsatiety signals to limit intake. Demonstration and dissemination projects will show how these new concepts inindividualized weight management based on balanced dietary advice...
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Funding SchemeIP - Integrated Project