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Diet, obesity and genes

Objective

The rapid growth in the prevalence of obesity and associated co-morbidities, in particular the rise in childhoodobesity across Europe are major global health concerns. Susceptibility to obesity is determined largely bygenetic factors but the current epidemic is significantly influenced by lifestyle factors. Given our geneticbackground it is largely infeasible to self-regulate food intake in the current environment. Innovative scientificapproaches to the problem are needed. DiOGenes aims to respond by including all disciplines and stakeholderswho can contribute to a better understanding of the disease and its alleviation by dietary means. DiOGenes'primary dietary focus is on macronutrients that will facilitate a healthy weight, specifically the role of thecarbohydrate Glycmie Index and of a high protein content in enhancing satiety. To examine critically the dietaryimpact, an 8-country, long-term randomised, parallel dietary intervention study on whole families will take place.To identify gene-nutrient interactions linked with changes in body weight and waist circumference, DiOGenes isuniquely positioned trough access to long-term prospective cohorts across Europe. Large-scale longitudinalanalysis of variation in candidate genes, plus approaches such as gene expression in fat tissue and plasmapeptidomics, will search for genetic biomarkers, ultimately enabling prediction of individuals' responses tonutrients in terms of weight change, in turn leading to diet-based treatment. The epidemiological and interventionstudies will be complemented by innovative analysis of the psychological/behavioural responses of subjects.Food technology studies will seek to develop food combining high consumer liking/preference with enhancedsatiety signals to limit intake. Demonstration and dissemination projects will show how these new concepts inindividualized weight management based on balanced dietary advice...

Call for proposal

FP6-2003-FOOD-2-A
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

UNIVERSITEIT MAASTRICHT
Address
Universiteitssingel 50
616 Maastricht
Netherlands

Participants (36)

DEN KONGELIGE VETERINAER- OG LANDBOHOEJSKOLE
Denmark
Address
Bulowsvej 17
Frederiksberg C
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20 Park Cresent
London
UNIVERSITY OF CRETE
Greece
Address
Knossos Avenue
Heraklion, Crete
DEUTSCHES INSTITUT FÜR ERNÄHRUNGSFORSCHUNG
Germany
Address
Arthur-scheunert Allee 114-116
Nuthetal
UNIVERSIDAD DE NAVARRA
Spain
Address
C/ Irunlarrea S/n
177 Pamplona
NATIONAL MEDICAL TRANSPORT INSTITUTE
Bulgaria
Address
108 Maria Luisa Blv
Sofia
NESTEC S.A.
Switzerland
Address
Avenue Nestle 55
Vevey
DANONE VITAPOLE
France
Address
R.d. 128
Palaiseau
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
France
Address
101, Rue De Tolbiac
Paris
INTEGRAGEN SA
France
Address
4, Rue Pierre Fontaine
Evry
BIOVISION AG
Germany
Address
Feodor-lynen-str. 5
Hannover
BISPEBJERK HOSPITAL
Denmark
Address
Bispebjerg Bakke 23
Copenhagen
BUDAPESTI MUSZAKI ES GAZDASAGTUDOMANYI EGYETEM
Hungary
Address
M_egyetem Rkp. 3.
Budapest
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU (RIVM)
Netherlands
Address
Anthonie Van Leeuwenhoeklaan 9
Bilthoven
CENTRO PER LO STUDIO E LA PREVENZIONE ONCOLOGICA
Italy
Address
Viale A. Volta 171
Florence
HELSINGIN YLIOPISTO
Finland
Address
Yliopistonkatu 4
Helsinki
ROWETT RESEARCH INSTITUTE
United Kingdom
Address
Greenburn Road
Bucksburn, Aberdeen
UNIVERSITY OF LEEDS
United Kingdom
Address
Woodhouse Lane
Leeds
UNIVERSITY OF SURREY
United Kingdom
Address

Guildford
HOCHSCHULE FÜR ANGEWANDTE WISSENSCHAFTEN
Germany
Address
Berliner Tor 5
Hamburg
STICHTING TOPINSTITUUT VOEDSELWETENSCHAPPEN
Netherlands
Address
Diedenweg 20
557 Wageningen
NIZO FOOD RESEARCH BV
Netherlands
Address
Kernhemseweg 2
Ede
NOFIMA MAT AS
Norway
Address
Osloveien 1
Aas
UNILEVER NEDERLAND BV
Netherlands
Address
Olivier Van Noortlaan 120
114 Vlaardingen
RICHARD HILL CONSULTING LTD
United Kingdom
Address
The Beeches, 45 Lodge Road
Sharnbrook, Bedford
NETUNION SARL
Switzerland
Address
Avenue Des Figuiers 20
Lausanne
CORTECNET
France
Address
110, Rue De Rivoli
Paris
DANISH CANCER SOCIETY
Denmark
Address
Strandboulevarden 49
839 Copenhagen
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Address
Exhibition Road
London
UNIVERSITY OF ANGERS
France
Address
40, Rue De Rennes
73532 Angers
KRAFT FOODS R&D INC.
Germany
Address
Bayerwaldstrasse 8
830550 Munich
MILES BRAMWELL EXECUTIVE SERVICES LTD
United Kingdom
Address
Clover Nook Road
Somercotes, Alfreton
DIGILAB BIOVISION GMBH
Germany
Address
Feodor Lynen-str. 5
Hannover
INSTITUTE OF ENDOCRINOLOGY
Czechia
Address
Narodni 8
Prague 1
UNIVERSITY OF COPENHAGEN
Denmark
Address
Noerregade 10
Copenhagen
PROTEOME SCIENCES PLC
United Kingdom
Address
Coveham House Downside Bridge Road
Cobham