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Design of Effective and sustainable control strategies for LIVER fluke in Europe

Objective

Liver fluke disease causes annual losses over 3 $US billion to livestock production and the food industry worldwide. Prevalence of fasciolosis is dramatically increasing ??? in recent years for example increases of up to 12 fold have been recorded in EU member states. In the UK the prevalence of infection in cattle ranges from 45% to 84%, and in Ireland alone annual losses have been estimated at ???60 million. Control of the disease in livestock is based in the use of anthelmintic drugs, with accompanying risks of chemical residues in foodstuffs; moreover, anthelmintic resistance is emerging as a problem in many areas of Europe and globally. Fasciolosis is also an emerging human disease in many INCO countries (an estimated 17 million people are infected). The aim of the DELIVER project is to develop new environmentally-friendly methods for the control of liver fluke disease in livestock, thereby minimising the use of anthelmintic drugs and enhancing the quality and safety of meat and dairy products. The project will integrate the work of 15 partners from 10 countries. Novel control methods will be developed through 1) Epidemiology: determination of risk factors and a predictive model for fasciolosis; standardisation of improved diagnostic tools in intermediate hosts, livestock and humans and determination of genetic diversity of European liver fluke populations. 2) Anthelmintic resistance: standardisation of field and in vitro assays for detecting anthelmintic resistance and measurement of triclabendazole resistance; determination of mechanisms of drug action and resistance in order to formulate new strategies for conservation of drug efficacies. 3) Immunoprophylaxis: development of protective vaccines, evaluation of the immunomodulatory impact of fasciolosis and investigation of the prospects of breeding animals innately resistant to infection. Guidelines for best practice in liver fluke control in livestock minimising the use of anthelmintic will be produced.

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Coordinator

UNIVERSIDAD DE CÓRDOBA

Address

Alfonso Xiii, 13
CÓRdoba

Spain

Participants (16)

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DUBLIN CITY UNIVERSITY

Ireland

NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

UNIVERSITY OF WALES, ABERYSTWYTH

United Kingdom

UNIVERSITY OF EXETER

United Kingdom

LIVERPOOL SCHOOL OF TROPICAL MEDICINE

United Kingdom

WITOLD STEFANSKI INSTITUTE OF PARASITOLOGY POLISH ACADEMY OF SCIENCES

Poland

QUEEN'S UNIVERSITY BELFAST

United Kingdom

ID-LELYSTAD, INSTITUUT VOOR DIERHOUDERIJ EN DIERGEZONDHEID BV

Netherlands

AGRICULTURAL UNIVERSITY OF ATHENS

Greece

INSTITUTE OF EXPERIMENTAL PATHOLOGY & PARASITOLOGY-BASC

Bulgaria

UNIVERSIDAD NACIONAL DEL CENTRO DE LA PROVINCIA DE BUENOS AIRES

Argentina

OSWALDO CRUZ FOUNDATION

Brazil

LARA MEDIA LTD.

Ireland

UNIVERSITY OF LIVERPOOL

United Kingdom

STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK

Netherlands

UNIVERSIDAD NACIONAL DE CAJAMARCA

Peru

Project information

Grant agreement ID: 23025

  • Start date

    1 February 2006

  • End date

    31 May 2009

Funded under:

FP6-FOOD

  • Overall budget:

    € 3 602 114

  • EU contribution

    € 3 540 000

Coordinated by:

UNIVERSIDAD DE CÓRDOBA

Spain