Objetivo The aim of this proposal is to explore the role of non-coding genetic information by identifying novel non-coding RNA genes (ncRNAs) and analyse their mechanisms of action and impact on cell differentiation and disease. We will concentrate on ncRNAs acting on post-transcriptional processes and bring together European laboratories with expertise in RNA biology, bioinformatics/prediction software and industrial exploitation of genomes. Using multidisciplinary functional genomic approaches, we will address a hitherto under-investigated topic and generate highly novel information on gene content and function in Arabidopsis thaliana, Caenorhibditis elegans, mouse and human. We will mine databases and use a large-scale genomic approach (RNomics) to search for new ncRNAs in diverse organisms and for their human orthologues. We will construct ncRNAs gene-chips and study their expression in different genetic backgrounds and cellular or developmental conditions, including cancer cell lines. Using multidisciplinary approaches, we will unravel new regulatory processes and mechanisms involving ncRNAs, highly informative by their generality and/or their direct relation to human diseases, We will study the composition of protein complexes containing the ncRNAs, their mode of action and impact. Altering ncRNA activity will be evaluated through transcriptome to identify potential targets in RNA-mediated developmental rocesses. The knowledge generated by this project is urgently required to correctly exploit the huge amount of sequence data available and to better integrate post-genomic research into biomédical and biotechnological approaches. This project will give European biotechnology industries a critical leading edge to exploit the full potential of genome information to underpin applications to human health. The proposed work will also provide knowledge to develop technologies and therapeutic tools based on RNA molecules. Ámbito científico natural sciencesbiological sciencescell biologymedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological scienceszoologymammalogynatural sciencesbiological sciencesgeneticsgenomes Palabras clave coding RNAs differentiation and disease non non-coding RNAs riboregulator Programa(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) LIFESCIHEALTH-1.2.5 - Innovative research in post-genomics, which has high potential for application LSH-2002-1.1.0-1 - Topics for Specific Targeted Research Project/CA in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Convocatoria de propuestas FP6-2002-LIFESCIHEALTH Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Aportación de la UE Sin datos Dirección 3 Rue Michel Ange PARIS Francia Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (8) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo AGRICULTURAL BIOTECHNOLOGY CENTER Hungría Aportación de la UE Sin datos Dirección Szent-Gyorgyi A. 4 411 GODOLLO Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE Francia Aportación de la UE Sin datos Dirección 147 rue de l'Université PARIS Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS España Aportación de la UE Sin datos Dirección C/Serrano. 117 MADRID Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos WESTFAELISCHE WILHELMS - UNIVERSITAET Alemania Aportación de la UE Sin datos Dirección Schlossplatz 2 MUENSTER Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos EXIQON A/S Dinamarca Aportación de la UE Sin datos Dirección Bygstubben 9 VEDBAEK Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos BIOTECGEN SRL Italia Aportación de la UE Sin datos Dirección Via Moline, 30 NOVOLI Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos BIOMEDAL S.L. España Aportación de la UE Sin datos Dirección Avda.Americo Vespuccio. 5-E SEVILLA Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos ERASMUS MEDICAL CENTER ROTTERDAM Países Bajos Aportación de la UE Sin datos Dirección Dr. Molewaterplein 50 1738 ROTTERDAM Ver en el mapa Coste total Sin datos
