CORDIS
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Rational Treatment Strategies Combating Mitochondrial Oxidative Phosphorylation (OXPHOS) Disorders

Project information

Grant agreement ID: 503116

  • Start date

    1 July 2004

  • End date

    30 June 2008

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 10 908 893

  • EU contribution

    € 8 196 135

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

Objective

Defects in the mitochondria! oxidative phosphorylation (OXPHOS-) system, the principal circuit for cellular energy production, lead to often fatal, multi-system disorders affecting organs and tissues with a high-energy demand. The EUMITOCOMBAT consortium, consisting of 12 partners, encompassing 21 scientific groups from nine different countries, including the Czech Republic, aims to integrate and extend knowledge on basic aspects of OXPHOS biology and the pathobiological cascades underlying OXPHOS disease manifestation in humans.
The EUMITOCOMBAT project will re-inforce Europe as the international leader in the development of treatments capable of combating these disorders. To this end we will:
- Integrate clinical and model-system expertise.
- Characterize important genes and proteins involved in the formation and regulation of the OXPHOS-system.
- Study the network of components involved in cellular energy metabolism by functional genomics.
- Develop more efficient genetic and protein (mutation) screening methods.
- Evaluate the cellular alterations/adaptations of these defects in specified cells, tissues, models and humans.
- Develop methods to target and test therapeutic agents to specific (sub)cellular locations.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT

Address

Geert Grooteplein 10
9101 Nijmegen

Netherlands

Participants (11)

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

UNIVERSIDAD DE ZARAGOZA

Spain

KAROLINSKA INSTITUTET

Sweden

MEDICAL RESEARCH COUNCIL

United Kingdom

INSTITUTE OF PHYSIOLOGY, ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

Czechia

CHARLES UNIVERSITY

Czechia

UNIVERSITY OF TAMPERE

Finland

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

UNIVERSITÀ DEGLI STUDI DI BARI

Italy

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

France

ISTITUTO NAZIONALE NEUROLOGICO "CARLO BESTA"

Italy

Project information

Grant agreement ID: 503116

  • Start date

    1 July 2004

  • End date

    30 June 2008

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 10 908 893

  • EU contribution

    € 8 196 135

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands