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Identification of molecular pathways that regulate the organ-specific metastasis of breast cancer

Objective

The objectives of this proposal are to identify genes, proteins and molecular pathways involved in regulating the metastasis of breast cancer to specific organs. To achieve these objectives we will use a combination of gene expression profiling, bioinformatic analysis, histology of human female breast cancer samples, genetic manipulation of transplantable tumour cells and transgenic mouse technology. In addition to finding new genes, we aim to analyse to what extent genes already known to play a role in breast cancer metastasis specify which organs breast tumours metastasise to. We will also establish how the currently known genes that are associated with breast cancer dissemination and the new ones we identify fit together into pathways that regulate organ- specific metastasis. These findings will be coupled with the analysis of clinical trials that participants in this consortium are involved in. Further deliverables include the development of improved animal models for the study of breast cancer metastasis, and the development of diagnostic methods for determining whether primary tumours already have metastatic potential. Together, the work packages in this proposal will establish a pipeline of activities that unite basic research into the organ-specific metastasis of breast cancer with target validation and clinical application.

Call for proposal

FP6-2002-LIFESCIHEALTH
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Coordinator

FORSCHUNGSZENTRUM KARLSRUHE GMBH
Address
Weberstr. 5
Karlsruhe
Germany

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Participants (14)

FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY
Belgium
Address
Rijvisschestraat 120
Gent (Zwijnaarde)

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UNIVERSITY OF BASEL
Switzerland
Address
Petersgraben 35
Basel

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DANISH CANCER SOCIETY, INSTITUTE OF CANCER BIOLOGY
Denmark
Address
Strandboulevarden 49
Copenhagen

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INSTITUT CURIE
France
Address
26 Rue D'ulm
Paris

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G2M CANCER DRUGS AG
Germany
Address
Paul-ehrlich-strasse 42-44
Frankfurt Am Main

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UNIVERSITÉ DE LIÈGE
Belgium
Address
Place Du Xx Août, 7
Liège

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THE NETHERLANDS CANCER INSTITUTE
Netherlands
Address
Plesmanlaan 121
Amsterdam

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CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS
Germany
Address
Paul-ehrlich-str. 42-44
700251 Frankfurt Am Main

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FONDAZIONE TELETHON
Italy
Address
Via G. Saliceto, 5
Rome

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CENTRE NATIONAL DE LA RECHERQUE SCIENTIFIQUE
France
Address
3, Rue Michel-ange
Paris

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CEINGE BIOTECNOLOGIE AVANZATE S.C.A.R.L.
Italy
Address
Via Comunale Margherita 482
Naples

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LEIDS UNIVERSITAIR MEDISCH CENTRUM
Netherlands
Address
Wassenaarseweg 72
9503 Leiden

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CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN, CAMPUS BUCH
Germany
Address
Lindenberger Weg 80
Berlin

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JOHANNES GUTENBERG-UNIVERSITÄT MAINZ
Germany
Address
Saarstr. 21
Mainz

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