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Mucosal Vaccines for Poverty Related Diseases

Objective

The project is focused on the development of mucosal vaccines against AIDS and tuberculosis (TB) and is based on the use of antigens validated as safe and effective in animal models. Mucosal vaccines present advantages of practical and social relevance when compared to parenteral. To ensure vaccine compliance, accessibility, and coverage, vaccines should be designed which can be administered by convenient mucosal routes of delivery. Mucosal vaccines, inducing both local and systematic immune responses, are considered moreeffective in controlling mucosally-acquired infections, such as HIV and TB.

The project consists of two major parallel interlinked tracks: i) phase I trials of mucosal immunization using antigens and adjuvants validated in previous preclinical and clinical studies ii) development of new candidate vaccines for mucosal immunization and their comparative selection in animal models. Antigens such as GAg, V2-deleted gp 120, Tat (HIV-1), and Ag85B/ESAT-6 hybrid molecule (TB), and adjuvants such as LTK63 and HSP70, will be used in combination for phase I trials to be performed first in Europe and than in Africa Development of new vaccine candidates will not include antigen discovery but would rather be based on the novel use of adjuvants and delivery systems in combination with promising antigens. Animal models of increasing relevance for human vaccines will be used to compare new candidates and to select those which should proceed to phase I trials.

The final expected result of this Project is to provide candidate mucosal vaccines, with proved safety and immunogenicity in humans, that could subsequently enter the path towards licensure through phase II and III clinical trials. The European Developing Countries Clinical Trials Partnership which is expected to be soon operative could be instrumental in exploiting the results obtained in this project by testing mucosalvaccines against these devasting diseases in developing countries.

Field of science

  • /medical and health sciences/health sciences/public and environmental health/epidemics prevention/immunisation
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

IP - Integrated Project
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Coordinator

NOVARTIS VACCINES AND DIAGNOSTICS SRL
Address
Via Fiorentina N.1
Siena
Italy

Participants (29)

GENOME RESEARCH LIMITED
United Kingdom
Address
183 Euston Road
London
GOETEBORG UNIVERSITY
Sweden
Address
Vasaparken
100 Goeteborg
UNIVERSITA DEGLI STUDI DI SIENA
Italy
Address
Via Banchi Di Sotto, 55
Siena
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Hofgartenstrasse 8
101062 Muenchen
ISTITUTO SUPERIORE DI SANITA
Italy
Address
Viale Regina Elena 299
Rome
INSTITUTE FOR RESEARCH IN BIOMEDICINE
Switzerland
Address
Via Vincenzo Vela 6
Bellinzona
BERNHARD-NOCHT-INSTITUTE FOR TROPICAL MEDICINE
Germany
Address
Bernhard-nocht-strasse 74
Hamburg
KINGS COLLEGE LONDON
United Kingdom
Address
Strand
London
THE PROVOST,FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE
Ireland
Address
College Green
Dublin
STATENS SERUM INSTITUTE
Denmark
Address
Artillerivej 5
Copenhagen
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Address
Piazzale Aldo Moro, 7
Roma
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
Address
Via Eritrea 62
Milano
DEUTSCHES RHEUMA-FORSCHUNGSZENTRUM BERLIN
Germany
Address
Schumannstrasse 21-22
Berlin
ST. GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
Address
Cranmer Terrace
London
INSTITUTE OF MICROBIOLOGY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
Czechia
Address
Videnska 1083
Prague
HEALTH PROTECTION AGENCY
United Kingdom
Address
Porton Down
Salisbury, Wiltshire
UNIVERSITY OF FLORENCE - DEPARTMENT OF INTERNAL MEDICINE
Italy
Address
Viale Margagni 85
Firenze
UNIVERSITY OF LAUSANNE
Switzerland
Address

Lausanne
ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE S.R.L.
Italy
Address
Via Nino Bixio 15
Siena
LIONEX DIAGNOSTIC & THERAPEUTICS GMBH
Germany
Address
Mascheroder Weg 1 B
Braunschweig
INOTECH AG
Switzerland
Address
Kirchstrasse 1
Dottikon
HUMANITAS MIRASOLE SPA
Italy
Address
Via Manzoni 56
Rozzano-milano
SOUTH AFRICAN MEDICAL RESEARCH COUNCIL
South Africa
Address
Francie Van Zijl Drive, Parow
19070 Cape Town
THE ARMAUER HANSEN RESEARCH INSTITUTE
Ethiopia
Address
Alert Campus, Jimma Road
1005 Addis Ababa
UNIVERSITA DI PALERMO
Italy
Address
Corso Tukor 211
Palermo
BIOMEVA GMBH
Germany
Address
Czernyring 22
101280 Heidelberg
LPT LABORATORY OF PHARMACOLOGY AND TOXICOLOGY GMBH & CO. KG
Germany
Address
Redderweg 8
920461 Hamburg
INOTECH LABOR AG. IN LIQ.
Switzerland
Address
Malzgasse 15
CENTRE-HOSPITALIER-UNIVERSITAIRE IGNACE DEEN CONAKRY
Guinea
Address

B.P.634 Conakry