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European Vascular Genomics Network

European Vascular Genomics Network

Objective

Cardiovascular diseases (CVD) caused 51% of deaths in Europe in 2001.Coronary heart disease and stroke, which result from atherosclerosis, constitute 80% of CVD. Better prevention and treatments have halved age-specific incidence, but the ageing population and adverse trends in obesity and diabetes threaten these improvements. There is also an alarming increase in heart failure, the end stage of coronary heart disease. Future advances depend on developing entirely new strategies. Genomics and proteomics together complete human genome open up fresh horizons for molecular understanding of cardiovascular disease, for identifying new diagnostic measurements and developing new pharmacological, gene and cell-based therapies. The European Vascular Genomics Network (EVGN) assembles the necessary critical mass and promotes multidisciplinary interactions by uniting 25 world-leading basic and clinical institutions from 9 European countries. It focusses on the three areas with greatest therapeutic potential: 1) endothelial dysfunction, an early critical event in atherosclerosis and hence a target for prevention, 2) plaque instability, responsible for precipitating thrombosis and hence most life-threatening acute events, and 3) therapeutic angiogenesis either conventional or cell-based to recover ischaemic organ function and reduce heart failure. Our research armoury spans genomics, proteomics, molecular biology, cell biology, gene transfer and genetic modification in mice, and integrative pathophysiology in man. The EVGN will maximize the scientific and commercial potential of European vascular biology by electronic data-sharing and communication networks, shared research tools, and exchange and training programmes. The EVGN will train tomorrow's lead investigators through a European training programme for PhD students, which will also address adverse gender balance and encourage excellence in Eastern Europe, which suffers high prevalence of CVD.

Coordinator

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

Address

101, Rue De Tolbiac
Paris

France

Administrative Contact

Alain TEDGUI (DR)

Participants (33)

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THE UNIVERSITY OF BRISTOL

United Kingdom

CHANCELLORS MASTER AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

CARDIOVASCULAR RESEARCH INSTITUTE MAASTRICHT

Netherlands

KAROLINSKA INSTITUTET

Sweden

FONDAZIONE IFOM ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE

Italy

UNIVERSITY OF ZURICH

Switzerland

MEDICAL UNIVERSITY VIENNA

Austria

VU MEDICAL CENTER

Netherlands

ACADEMIC MEDICAL CENTER, UNIVERSITY OF AMSTERDAM

Netherlands

VITA-SALUTE SAN RAFFAELE UNIVERSITY

Italy

UNIVERSITY OF KUOPIO

Finland

UNIVERSITY OF TORINO

Italy

NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS

Italy

ST. GEORGE'S HOSPITAL MEDICAL SCHOOL'

United Kingdom

THE HEBREW UNIVERSITY OF JERUSALEM

Israel

THE UNIVERSITY OF BIRMINGHAM

United Kingdom

UNIVERSITY COLLEGE LONDON

United Kingdom

UNIVERSITY OF GENEVA

Switzerland

ARK THERAPEUTICS GROUP LIMITED

United Kingdom

TECHNOCLONE GMBH

Austria

INSERM-TRANSFERT SA

France

JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE

Poland

JAGIELLONIAN UNIVERSITY

Poland

SILESIAN SCHOOL OF MEDECINE

Poland

KING'S COLLEGE LONDON

United Kingdom

CENTRE EUROPÉEN DE RECHERCHE EN BIOLOGIE ET EN MÉDECINE (GIE)

France

FONDAZIONE ITALIANA PER LA RICERCA SUL CANCRO ONLUS

Italy

JOHANN WOLFGANG GOETHE-UNIVERSITÄT

Germany

JOHANNES GUTENBERG-UNIVERSITÄT MAINZ

Germany

MEDIZINISCHE UNIVERSITÄT INNSBRUCK

Austria

RHEINISCHE-FREIDRICH-WILHEMS-UNIVERSITÄT MEDIZINISCHE FAKULTÄT BONN

Germany

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

Germany

UNIVERSITÄT LEIDEN

Netherlands

Project information

Grant agreement ID: 503254

  • Start date

    1 January 2004

  • End date

    31 December 2008

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 58 795 327

  • EU contribution

    € 9 000 000

Coordinated by:

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

France