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Extracellular Proteases and the Cances Degradome: Innovative Diagnostic Markers, Therapeutic Targets and Tumour Imaging Agents

Objective

The European Cancer Proteases Consortium (EUCPC) proposes multidisciplinary research into innovative approaches for cancer therapy and diagnosis based on the DEGRADOME - the repertoire of extracellular proteases through which cells regulate their local environment. Extracellular proteases remain an attractive target for intervention against cancer, even if first generation anti-protease drugs were disappointing in clinical trials. We now appreciate that proteases have complex roles with distinct functions at different stages of tumour development and progression, and may have conflicting effects on malignancy. We now propose to put these recent insights into pre-clinical and clinical settings. Using four common human malignancies - breast, prostate, colorectal and skin cancer - the EUCPC will employ a combination of strategies involving cell and mouse models, patient tissues, molecular profiling and modelling techniques, as well as physical and molecular imaging of tumours using MRI and PET. The 28 academic and 5 SME Participants combine expertise in genomics, bioinformatics, protein-protein interactions, proteomics, gene expression, molecular diagnostics and pathology, knockout mice and mouse models of cancer, synthetic chemistry, protein structure, drug development and tumour imaging. The EUCPC will facilitate access to shared technologies, data analysis and knowledge dissemination. In this 4 year Integrated Project the EUCPC aims to: 1) Define new molecular targets for drug design. 2) Develop novel specific interventions that are based on thorough knowledge of the pathophysiological roles of target proteases and related molecules, and understand how and when to use them. 3) Identify new molecular diagnostic and prognostic indicators of patient risk that can improve health care delivery based on an individualized, patient-oriented approach to therapy. 4) Provide new ways to enhance visualization of tumours in the clinic.

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

UNIVERSITY OF EAST ANGLIA
Address
University Plain
Norwich
United Kingdom

Participants (35)

THE FINSEN LABORATORY, COPENHAGEN UNIVERSITY HOSPITAL
Denmark
Address
Strandboulevarden 49
Copenhagen
INSTITUTO FIRC DI ONCOLOGIA MOLECULARE
Italy
Address
Via Corridoni, 7
Milan
UNIVERSITÉ DE LIÈGE
Belgium
Address
Place Du Xx Août, 7
Liège
UNIVERSIDAD OVIEDO
Spain
Address
C/san Francisco, 2
Oviedo
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge
KAROLINSKA INSTITUTET
Sweden
Address
Nobels Väg 5
Stockholm
COMMISSARIAT A L'ENERGIE ATOMIQUE
France
Address
31-33 Rue De La Fédération
Paris
UNIVERSITAIRE ZIEKENHUIZEN LEUVEN (GASTHUISBERG)
Belgium
Address
Herestraat, 49
Leuven
UNIVERSITY OF TURKU
Finland
MEDICAL UNIVERSITY VIENNA
Austria
Address
Spitalgasse 23
Vienna
NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS
Greece
Address
6 Chr. Lada Street
Athens
STIFTELSEN CENTRUM FOR MOLEKULAR MEDICIN/ CENTER FOR MOLECULAR MEDICINE FOUNDATION
Sweden
Address
Cmm L8:01, Ks Ringen 6, Karolinska University Hospital
Stockholm
UNIVERSITY OF FREIBURG
Germany
Address
Stefan-meier-str. 17, 79104 Freiburg
79106 Freiburg
NATIONAL INSTITUTE OF BIOLOGY
Slovenia
Address
Vecna Pot 111
141 Ljubljana
ISTITUTO DI RICERCHE FARMACOLOGICHE "MARIO NEGRI"
Italy
Address
Via Eritrea 62
Milan
UNIVERSITAETSKLINIKUM HEIDELBERG
Germany
Address
Im Neuenheimer Feld 672
Heidelberg
UNIVERSITY OF GLASGOW
United Kingdom
Address
University Avenue
Glasgow
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET EN MEDICINE (GIE)
France
Address
1 Rue Laurent Fries
10142 Iiikirch
TECHNICAL UNIVERSITY OF MUNICH
Germany
Address
Ismaninger Str.22
München
PROTEROS BIOSTRUCTURES GMBH
Germany
Address
Am Klopferspitz, 19
Martinsried
DEUTSCHES KREBSFORSCHUNGSZENTRUM
Germany
Address
Im Neuenheimer Feld 280
101949 Heidelberg
UNIVERSITY OF AARHUS
Denmark
Address
Nordre Ringgade 1
Aarhus C
INSTITUTE OF GENETICS AND BIOPHYSICS "ADRIANO BUZZATI-TRAVERSO", NATIONAL RESEARCH COUNCIL
Italy
Address
Via Marconi 10
Napoli
ISTITUTO DI ENDOCRINOLOGIA E ONCOLOGIA SPERIMENTALE "G.SALVATORE", CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Address
Via S. Pansini 5
Naples
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Serrano, 117
Madrid
QUEEN MARY, UNIVERSITY OF LONDON
United Kingdom
Address
3Rd Floor, Rutland House, 42-46 New Road
London
ONCOMETHYLOME SCIENCES S.A. (EX-ONCOGENOME SCIENCES S.A.)
Belgium
Address
Avenue Maurice Destenay 13
Liege
GENOPTICS S.A.
France
Address
Centre Scientifique - Bât. 503
Orsay
UNIVERSITEIT GENT
Belgium
Address
Sint-pietersnieuwstraat 25
Gent
KRKA D.D., PHARMACEUTICAL COMPANY
Slovenia
Address
Smarjeska 6
Novo Mesto
INSTITUTE OF PATHOLOGY, CANTONAL HOSPITAL, UNIVERSITY OF BASEL
Switzerland
Address
Schoenbeinstr. 40
Basel
HUMBOLDT UNIVERSITY
Germany
Address
Unter Den Linden 6
Berlin
UNIVERSITY OF SOUTHAMPTON
United Kingdom
Address
Highfield
Southampton
GNOTHIS AB
Sweden
Address

Electrum Kista
MAX-PLANCK-SOCIETY FOR THE ADVANCEMENT OF SCIENCE
Germany
Address
Hofgartenstrasse 8
Munchen