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Abnormal proteins in the pathogenesis of neurodegenerative disorders

Objective

Degenerative disorders of the nervous system including Alzheimer's, Parkinson's, Huntington's, motor neuron and prion diseases are among the most debilitating illnesses, putting an enormous strain on both social and health care budgets in Europe. As these diseases progress, all but the most primitive functions of the nervous system are lost due to the degeneration and subsequent death of nerve cells. Eventually patients die in a state of incapacitation. Only a small fraction of cases can be accounted for by gene mutations. Altogether, the underlying aetiologies are poorly understood. A hallmark common to these neurodegenerative disorders is the deposition of abnormal protein aggregates. There is currently no treatment available that can halt or prevent, let alone reverse nerve cell degeneration. The APOPIS project is designed to apply the unique information provided by sequencing of the human genome to further the understanding of and to develop treatments for these deva¬ stating diseases. By integrating Europe's leading research centres in clinical research, human genetics, cell biology, genomics, proteomics and bioinformatics, the VERUM Foundation has devised a consortium to identify genes involved, determine their biological functions, establish their role in the patho-physiological processes and identify novel avenues for early diagnosis, treatment and prevention. The chosen approach is based on human population genetics complemented by the identification of modifier genes in model organisms that express both wildtype and mutant variants of known disease-related genes. The consortium meets the prerequisites for such a project: ground breaking research in functional genomics related to human health, creating synergies with and between national research efforts, teaming up with both small biotechnology and pharmaceutical companies for the development of diagnostic tools and new drugs, and providing training and mobility to improve the skills of...

Call for proposal

FP6-2002-LIFESCIHEALTH
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Coordinator

VERUM - FOUNDATION FOR BEHAVIOUR AND ENVIRONMENT
Address
Pettenkoferstr. 33
Muenchen
Germany

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Participants (33)

FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW
Belgium
Address
Rijvisschestraat 120
Zwijnaarde

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UNIVERSITAET ZUERICH
Switzerland
Address
Raemistrasse 71
Zurich

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UNIVERSITAET BASEL
Switzerland
Address
Petersplatz 1
Basel

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ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Address
Ecublens
Lausanne

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EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
Address
Raemistrasse 101
Zurich

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ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
Address
Fahnenbergplatz
Freiburg

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LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Address
Geschwister-scholl-platz 1
Muenchen

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MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Hofgartenstrasse 8
101062 Muenchen

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TECHNISCHE UNIVERSITAET DARMSTADT
Germany
Address
Karolinenplatz 5
Darmstadt

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BAYERISCHE JULIUS-MAXIMILIANS UNIVERSITY OF WUERZBURG
Germany
Address
Sanderring 2
Wuerzburg

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MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE
Germany
Address
Robert-roessle-strasse 10
Berlin

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PARC CIENTIFIC DE BARCELONA
Spain
Address
Baldiri I Reixac, 10-12
Barcelona

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EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
Heidelberg

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INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
101 Rue De Tolbiac
Paris

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UNIVERSITE DE LILLE II
France
Address
Rue Paul Duez 42
Lille

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel Ange 3
287 Paris

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NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS
Greece
Address
Christou Lada Street 6
Athens

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THE HEBREW UNIVERSITY OF JERUSALEM - THE AUTHORYTY FOR RD
Israel
Address
Givat Ram Campus, Edmond Safra
Jerusalem

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FONDAZIONE CAVALIERI OTTOLENGHI
Italy
Address
Via Verdi 8
Torino (Turin)

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UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
Address
Via Olgettina 58
Milano

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CEINGE BIOTECNOLOGIE AVANZATE SCARL
Italy
Address
Via S.pansini, 5
Naples

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UNIVERSITA DEGLI STUDI DI GENOVA
Italy
Address
Via Balbi 5
Genova

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INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY
Poland
Address
Ks. Trojdena 4
Warszawa

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UNIVERSIDADE DE AVEIRO
Portugal
Address
Campo Universitario
Aveiro

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UPPSALA UNIVERSITET
Sweden
Address
St Olofsgatan, 10b
256 Uppsala

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LUNDS UNIVERSITET
Sweden
Address
Paradisgatan 5c
117 Lund

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UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London

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UNIVERSITY OF KENT
United Kingdom
Address
The University Of Kent At Canterbury
Canterbury

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KING'S COLLEGE LONDON
United Kingdom
Address
Strand
London

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THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge

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EVOTEC NEUROSCIENCES GMBH
Germany
Address
Schnackenburgallee 114
Hamburg

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CELLZOME AG
Germany
Address
Meyerhofstrasse 1
Heidelberg

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PHILIPPS UNIVERSITY MARBURG
Germany
Address
Biegenstrasse 12
Marburg

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