Obiettivo Depression is common and affects twice as many women as men. In the global burden of disease survey, it is the fourth most prevalent cause of disability, greater than eg cardiovascular disease. Gender, social and familial factors increase risk for depression, but little is known about how these influences work in the brain, least of all at the molecular level. Newer antidepressant treatments still act in the same way as 30 years ago and their downstream molecular actions are obscure. At most 65% of new episodes respond to drug-treatment and chronic, treatment-resistant depression is a major health burden.This is a major collaboration between 13 clinical and basic science groups in 10 EU countries whichaddresses the evident need to discover:New molecular mechanisms in the causation of depression.New molecular mechanisms of effective drug-treatment.We will measure three fundamental processes underlying depression - the inability to experience pleasure, excessive sensitivity to stress and negative appraisal of circumstances. This will enable us to cross-validate findings, in humans and animal models. In animals we will use a mixture of well-established and novel methods for inducing genetic and mild stress-related changes in the three processes. We will detect the molecular mechanisms involved by creating the NEWMOOD microarray chip and measuring changes in gene expression. Changes which are consistent across many models will become targets for new treatments. In addition we will search for neurochemical changes in how monoamine and other neurones are regulated which are shared by the models. These too will become new molecular targets.Humans with varying genetic and environmental risk factors will be compared on the three behaviours and on the brain systems and neurotransmitters responsible using functional magnetic resonance imaging. Campo scientifico medical and health sciencesclinical medicinecardiologycardiovascular diseasesengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging Parole chiave Depression affective disorder drug drug-treatment genetics neurotransmitters treatment Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2002-2.1.3-1 - Genomics and neurobiology of affective disorders LSH-2002-2.1.3-5 - Molecular and cellular basis of brain development Invito a presentare proposte FP6-2002-LIFESCIHEALTH Vedi altri progetti per questo bando Meccanismo di finanziamento IP - Integrated Project Coordinatore THE UNIVERSITY OF MANCHESTER Contributo UE Nessun dato Indirizzo OXFORD ROAD MANCHESTER Regno Unito Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (13) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contributo UE Nessun dato Indirizzo Rue de Tolbiac 101 PARIS Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF WUERZBURG Germania Contributo UE Nessun dato Indirizzo Sanderring 2 WUERZBURG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITAT POMPEU FABRA Spagna Contributo UE Nessun dato Indirizzo C/Dr Aiguader 80 BARCELONA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF TARTU Estonia Contributo UE Nessun dato Indirizzo Ülikooli18 TARTU Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF MAASTRICHT Paesi Bassi Contributo UE Nessun dato Indirizzo Universiteitssingel 50 616 MAASTRICHT Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato NATIONAL INSTITUTE OF PSYCHIATRY AND NEUROLOGY Ungheria Contributo UE Nessun dato Indirizzo Huvosvolgyi ut 116 BUDAPEST Mostra sulla mappa Costo totale Nessun dato THE UNIVERSITY OF EDINBURGH Regno Unito Contributo UE Nessun dato Indirizzo Old College, South Bridge EDINBURGH Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Regno Unito Contributo UE Nessun dato Indirizzo University Offices, Wellington Square OXFORD Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato KAROLINSKA INSTITUTET Svezia Contributo UE Nessun dato Indirizzo Retzius väg 8 STOCKHOLM Mostra sulla mappa Costo totale Nessun dato UNIVERSITÀ DEGLI STUDI DI FIRENZE, DIPARTIMENTO DI FARMACOLOGIA PRECLINICA E CLINICA Italia Contributo UE Nessun dato Indirizzo Piazza San Marco 4 FIRENZE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF NAVARRA Spagna Contributo UE Nessun dato Indirizzo Pamplona 177 NAVARRA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUTE OF GENETICS & ANIMAL BREEDING OF THE POLISH ACADEMY OF SCIENCES Polonia Contributo UE Nessun dato Indirizzo JASTRZEBIEC, POSTEPU 1 WOLKA KOSOWSKA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato SEMMELWEIS EGYETEM Ungheria Contributo UE Nessun dato Indirizzo Üllöi út 26 BUDAPEST Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato