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TARGETING TUMOUR-VASCULAR/MATRIX INTERACTIONS

Objective

This project intends to explore and validate new targets and pathways for innovative treatment of solid tumors directed towards tumor vascular matrix interactions, define validated targets towards tumour neovessel formation and create effective and tumour-selective strategies that complement or subsitute established therapies. The apparent lack of success in translating angiogenesis research into the clinic is in our view based on the fact that the research field is fragmented, and no standardized tools and models have been identified that reliably reflect the complexity of tumour angiogenesis mechanisms in humans. This integrated project will identify and validate new therapeutic targets directed towards tumor vascular-matrix interactions, develop new therapeutic strategies and implement such strategies in pre- and clinical trials. The project will represent a virtual research institute ine Europe and consists of 14 higly competent research centers within the field of angiogenesis research. To define and validate new targets related to the tumour vascular transcriptome and proteome, the consortium will etablish high throughput functional screening technologies for the identification of novel secreted factors that regulate endothelial cell growth and survival. This includes the use of robotics platforms that will be used to identify cDNAs with specific cellular functions. In this application, basic science, translational research and clinical activities are strongly intergrated, in order to validate defined targets and new therapeutic principles for clinical implementation.

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

UNIVERSITETET I BERGEN
Address
Muséplass 1
Bergen
Norway

Participants (15)

ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
Address
Via Filodrammatici, 10
Milan
UPPSALA UNIVERSITET
Sweden
Address
St Olofsgat 10B
Uppsala
LEIDS UNIVERSITAIR MEDISCH CENTRUM
Netherlands
Address
Wassenaarseweg 72
9503 Leiden
KTB TUMORFORSCHUNGS GMBH
Germany
Address
Breisacher Strasse 117
Freiburg
MAASTRICHT UNIVERSITY / RESEARCH INSTITUTES GROW AND CARIM
Netherlands
Address
Minderbroedersberg 4-6 6211 Lk
Maastricht
CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
VU UNIVERSITY MEDICAL CENTER
Netherlands
Address
De Boelelaan 1117
Amsterdam
UNIVERSITY OF OULU
Finland
Address
Pentti Kaiteran Katu 1
Oulu
INSTITUTE OF EXPERIMENTAL MEDICINE, ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
Czechia
Address
Videnska 1083
Prague 4
KAROLINSKA INSTITUTET
Sweden
Address
Nobels Väg 5
Stockholm
PHARMA TARGET B.V.
Netherlands
Address
Oxfordlaan 70
Maastricht
XANTOS BIOMEDICINE AG
Germany
Address
Max-lebsche-platz 31
Munich
CENTRE DE RECHERCHE PUBLIC SANTÉ
Luxembourg
Address
18, Rue Dicks
Luxembourg
CHARITÉ UNIVERSITÃTSMEDIZIN BERLIN
Germany
Address
Charitéplatz 1
Berlin
RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
Germany
Address
Seminarstr. 2
Heidelberg