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Functional Proteomics: Towards defining the interaction proteome

Objective

The aim of INTERACTION PROTEOME is to establish Europe as the international scientific leader in functional proteomics, i.e. in the analysis of protein-protein interactions. Major objectives include the establishment of a broadly applicable platform of routine methods for the analysis of protein interaction networks. A multidisciplinary appoach is laid out to address different aspects of the generation of protein-interaction data; their validation by cell biological, biochemical and biophysical methods; their collection in a new type of public database; and their exploitation and use for in silico simulations of protein-interaction networks. INTERACTION PROTEOME will develop novel technology, including a high-end mass spectrometer with extremely large dynamic range, high density peptide arrays, and improved visualisation technology for light and electron microscopy. Using the novel technology, the interaction partners of more than 100 relevant protein domains and more than 3.000 peptides will be characterised. Data obtained in the project will be collected in an improved version of the European MINT database. In parallel, novel bioinformatics tools for the prediction of protein interactions and their relation to post-translational modifications will be created. Software for in silico modeling of protein interactions will be developed and validated with the projects model systems. Each of these objectives represents a substantial advance of the state of the art in these technologies. The innovations generated in INTERACTION PROTEOME thus will provide the basis for an efficient analysis and systems modeling of fundamental biological processes in health and disease.

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

MAX PLANCK SOCIETY FOR THE ADVANCEMENT OF SCIENCE, REPRESENTED BY MPI OF BIOCHEMISTRY
Address
Am Klopferspitz 18
Martinsried
Germany

Participants (11)

BEATSON INSTITUTE FOR CANCER RESEARCH
United Kingdom
Address
Switchback Road, Garscube Estate
Glasgow
CENTRE DE REGULACIÓ GENÒMICA
Spain
Address
Passeig Maritim, 37-49
Barcelona
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
Heidelberg
FEI ELECTRON OPTICS B.V.
Netherlands
Address
Achtseweg Noord 5
Eindhoven
FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW
Belgium
Address
Rijvisschestraat 120
Zwijnaarde
GSF-FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT GMBH
Germany
Address
Ingolstaedter Landstrasse 1
Neuherberg
JERINI AG
Germany
Address
Invalidenstr. 130
Berlin
JPT PEPTIDE TECHNOLOGIES GMBH
Germany
Address
Invalidenstrasse 130
Berlin
TECHNICAL UNIVERSITY OF DENMARK
Denmark
Address
Anker Engelundsvej
Lyngby
UNIVERSITY OF ROME TOR VERGATA
Italy
Address
Via Carnevale
Rome
UNIVERSITY OF SOUTHERN DENMARK
Denmark
Address
Campusvej 55
Oidense