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Molecular Imaging for Biologically Optimised Cancer Therapy

Objective

Early tumour detection and response monitoring require maximum sensitivity and specificity of the imaging methods. The programme focuses on the clinical evaluation and development of new more specific molecular tracers for the early detection of tumour cells. A large number of new and potentially more specific tracers than fluorodeoxyglucose (FDG) will be tested including amino-acid analogues, small tumour-binding peptides, aptamers, peptides binding to mutant p53 proteins and nanoparticles. The more tumour specific the tracer, the more accurately it will be possible to image the true tumour cell density, and more importantly, the true response of the tumour to therapy. There is also a need to consolidate the experience in the use of recently developed molecular tracers to assess radiotherapy and chemotherapy response in order to improve on state of the art treatments. To maximise the sensitivity and tumour image quality, a high-resolution, wide field-of-view, ultra-sensitive PET-CT camera, capable of imaging half the human body in a few minutes, will be developed. New adaptive therapy planning and biological optimisation codes and a dedicated PET-CT detector for incorporation in treatment units will be designed in close corporation between university researchers and SME's. This will allow an efficient clinical integration and high patient throughput. The associated increase in accuracy of tumour imaging and three-dimensional in vivo tumour responsiveness data will hopefully allow the clinical introduction of accurate biologically based adaptive treatment optimization methods. Some of the work-packages will try to conenct to teh Genpe, Emir and Enlight programmes but do not depend on these programmes.

Call for proposal

FP6-2002-LIFESCIHEALTH
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Funding Scheme

IP - Integrated Project

Coordinator

KAROLINSKA INSTITUTET
Address
Nobels Väg 5
Stockholm
Sweden

Participants (20)

AARHUS UNIVERSITY HOSPITAL
Denmark
Address
Nørrebrogade 44
Aarhus C
C-RAD IMAGING AB
Sweden
Address
Önesslingan 5
Frösön
C-RAD INNOVATION AB
Sweden
Address
Fogdvreten 2 A
Stockholm
EUROPEAN ORGANIZATION FOR NUCLEUR RESEARCH
Switzerland
EUROPEAN SOCIETY FOR THERAPEUTIC RADIOLOGY AND ONCOLOGY
Belgium
Address
Av E Mounierlaan 83
Brussels
FORSCHUNGSZENTRUM DRESDEN-ROSSENDORF E.V.
Germany
Address
Bautzner Landstrasse 128
Dresden
INSTITUT GUSTAVE ROUSSY
France
Address
39 Rue Camille Desmoulins
Villejuif
PEVIVA AB
Sweden
Address
Strömkarlsvägen 82
Bromma
RAYCLINIC AB
Sweden
Address
Fogdevreten 2A, Karolinska Science Park, Karolinska Institutet
Stockholm
RAYSEARCH LABORATORIES AB
Sweden
Address
Sveavaegen 25
Stockholm
STICHTING KATHOLIEKE UNIVERSITEIT, UMC ST RADBOUD
Netherlands
Address
Geert Grooteplein 32
Nijmegen
THE ANDRZEJ SOLTAN INSTITUTE FOR NUCLEAR STUDIES
Poland
Address

Otwock/swierk
THE NETHERLANDS CANCER INSTITUTE
Netherlands
Address
Plesmanlaan 121
Amsterdam
THE UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
Manchester
UNIVERSITEIT MAASTRICHT
Netherlands
Address

Maastricht
UNIVERSITY HOSPITAL GASTHUISBERG
Belgium
Address
Herestraat 49
Leuven
UNIVERSITY OF HAMBURG
Germany
Address
Moorweidenstraße 18
Hamburg
UNIVERSITY OF TECHNOLOGY DRESDEN
Germany
Address
Helmholtzstrasse 10
Dresden
UNIVERSITY OF TURKU
Finland
UNIVERSITÉ CATHOLIQUE DE LOUVAIN
Belgium
Address
Place De L'université 1
Louvain-la-neuve