Specific biochemical reactions and their economical operations are the main advantages of bioreactors. They are widely applied in the industrial sector such as in the food and pharmaceutical industries, in bio technology and in municipal wastewater treatme nt plants. The biotechnological fermentation industry in Europe is faced with enormous legal restrictions such as the genetic law, embryonic protection law and so on. The fermentation industry lacks possibility for expansion due to the fact that new inst allations require new locations with the associated high investment costs There is a substantial need for compact and cost efficient biological fermentation system The intensive scientific efforts of the last 20 years in the genetic optimisation of the mi cro-organisms and in the classical bio-processes led to a drastically increase in the application of biotechnology in central Europe and to a substantial need for compact and cost effective biological fermentation systems The already existing experience w ith direct intake of ultrasound into smallscale bioreactors would be transferred into a by-pass ultrasound reactor technology. This new process omits the ultrasoundsystem installed in bio- reactor. This important step would lead to the possibility to use a lready existing bioreactors in the fermentation companies such as the food processing and biotechnology industries. With this type of reactor, a direct scale-up is quite possible Otherwise, the integration of the ultrasound in already existing fermentation reactors would lead to high investment and energy costs Ultrasound-systems will be coupled with biotechnology fermentation process to prove the already achieved results from Ultrasound-activated food processing