The project proposed is therefore a radically new approach to fabricate safe bioactive materials for tissue engineering and regenerative medicine. We propose to use cells as micro-factories to produce and assemble the molecular components at the nanometer level which is not possible by conventional mechanical engineering. This cellular engineering will be used to produce the supportive structure with desired shape, compliance and mechanical strength at meso- and macroscale levels. We achieve this by engine ering cells to express the desired components creating bioartificial scaffolds which mimick the natural extracellular matrix and will fulfil the requirements of mechanical support, compartmentalization, storage and sequestration of molecules. This also w ill have correct porosity allowing for diffusion of soluble molecules and access to cells, exposing ligands for adhesion and proliferation and being degradable by enzymatic mechanisms to allow body directed remodelling.
- FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006.
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