Bioreactive composite scaffold design for improved vascular connexion of tissue-engineered products

Projektinformationen

VASCUPLUG

ID Finanzhilfevereinbarung: 13811

Startdatum 1 April 2005

Enddatum 30 September 2008

Finanziert unter

• Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006.

Gesamtkosten € 3 160 761,00

EU-Beitrag € 2 300 000,00

Koordiniert durch

GKSS FORSCHUNGSZENTRUM GEESTHACHT GMBH
Germany

Ziel

Engineered tissues today in most cases lack appropriate connexion to the vascular system of the surrounding tissue in body at the implantation site. Hence the tissues suffer from malnutrition and low gas exchange leading to necrosis. To overcome this bottl eneck the strategic objective of this proposal is to develop a novel three-dimensional scaffold structure for improved vascularisation of tissue-engineered products. Application of intelligent biomaterials (bioresorbable stimuli-sensitive polymers) and inc orporation of bioactive substances (e.g. growth factors, monocyte-activating agents) will enhance a structured vascularisation of tissue-engineered constructs by gradually opening inserted microchannels for vessel ingrowth into cell-seeded polymeric scaffo lds. Furthermore, the mechanism of induction of secondary angiogenesis by monocytes will be used to control vascularisation. The signal for the stimulus-sensitive polymer to act (induction of angiogenesis) is intended to be a pH drop associated with malnut rition of cells.The use of angiogenic factors in promoting vascularisation of tissue-engineered constructs so far was performed by a rather isotropic distribution of factors in the scaffolds preventing the build-up of a gradient of bioactive substances for directed cell growth (angiogenesis). In our approach the tubular structure of the microchannels opened up upon activation of stimuli-sensitive filaments will guide cells involved in vascularisation and/or will provide a gradient for directed cell migratio n and growth. The composite scaffold giving rise to evolving vessels is intended to provide the vascular connexion to the surrounding tissue in the course of wound healing. The complex bunch of requirements for a functional vascularisation of tissue-engine ered products calls for a strong inter- and transdisciplinary cooperation of chemists, biologists, engineers, physicists and physicians depending on a pronounced cross-frontier collaboration.

Wissenschaftliches Gebiet

• engineering and technology › environmental biotechnology › bioremediation › bioreactors
• medical and health sciences › basic medicine › medicinal chemistry
• medical and health sciences › medical biotechnology › tissue engineering
• natural sciences › chemical sciences › polymer sciences
• medical and health sciences › medical biotechnology › cells technologies

Programm/Programme

• FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006.

Thema/Themen

• NMP-2003-3.4.2.2-3 - Intelligent' bio-materials for tissue repair and regeneration

Aufforderung zur Vorschlagseinreichung

FP6-2003-NMP-TI-3-MAIN
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

STREP - Specific Targeted Research Project

Koordinator

GKSS FORSCHUNGSZENTRUM GEESTHACHT GMBH

• EU-Beitrag: Keine Daten
• Adresse: Max-Planck-Strasse 1 ; GEESTHACHT ; Deutschland
• Gesamtkosten: Keine Daten

Beteiligte (6)

UNIVERSITY OF PATRAS

Griechenland

• EU-Beitrag: Keine Daten
• Adresse: Rion ; PATRAS
• Gesamtkosten: Keine Daten

FORSCHUNGSZENTRUM KARLSRUHE GMBH

Deutschland

• EU-Beitrag: Keine Daten
• Adresse: Weberstrasse 5 ; KARLSRUHE
• Gesamtkosten: Keine Daten

UNIVERSITY OF NOTTINGHAM

Vereinigtes Königreich

• EU-Beitrag: Keine Daten
• Adresse: University Park ; NOTTINGHAM
• Gesamtkosten: Keine Daten

KAROLINSKA INSTITUTET

Schweden

• EU-Beitrag: Keine Daten
• Adresse: Nobelsväg 5 ; STOCKHOLM
• Gesamtkosten: Keine Daten

UNIVERSIDADE DE SANTIAGO DE COMPOSTELA

Spanien

• EU-Beitrag: Keine Daten
• Adresse: Pazo de San Xerome - Praza do Obradoiro, s/n ; SANTIAGO DE COMPOSTELA
• Gesamtkosten: Keine Daten

SEMMELWEIS UNIVERSITY

Ungarn

• EU-Beitrag: Keine Daten
• Adresse: Uelloei u 26 ; BUDAPEST
• Gesamtkosten: Keine Daten