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From cell-cell recognition to memory formation. New strategies for the treatment of dysfunctional plasticity, learning and memory

Objective

The PROMEMORIA project focuses on the role of cell recognition processes in normal and dysfunctional plasticity, learning and memory with the aim of developing compounds with a beneficial effect on diseases involving cognitive impairment. The consortium expects to discover new genes and proteins, identify novel pathogenic mechanisms and define new therapeutic strategies. This is highly relevant to the objectives of thecall: LSH-2003-2.1.3-2. The consortium consists of 18 leading teams from 11 countries, of which two are new EU-member states. It is composed of 14 academic partners and 4 SMEs. The partners cover a wide range of expertises and technical competencies required to address in an ambitious manner the full scope of the call. Thus, the consortium contains teams specialized in genetics, protein chemistry, neurophysiology, neuroanatomy, neurobiology, animal models of learning and behaviour, in vivo test systems for a very broad range of behaviour and learning phenomena. Moreover, there is a considerable expertise in drug screening and development. The proposal presents a series of subprojects focused on gene discovery, structural biology, synaptic plasticity at both the physiological and morphological level, and a number of models of deficient plasticity, learning and memory. Moreover, the focus of the project, neuronal cell adhesion molecules, is novel and unique. Recent research has shown that these molecules play key roles in learning and memory. They have a very broad distribution in the nervous system for which reason they are optimal targets for drug development. An efficient dynamic management structure is proposed with four key objectives: Integration of research results and early identification of new findings; training of future world leaders in this research area; dissemination of results to scientists, patients and the general public; the issue of 5-10 patents securing protection and transfer to European industry of PROMEMORIA discoveries.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

UNIVERSITY OF COPENHAGEN
Address
Nørregade 10
2177 Copenhagen
Denmark

Participants (17)

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
Address
College Green
Dublin
INSTITUTE OF NEUROLOGY - UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Queen Square
London
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
3 Rue Michel-ange
Paris
NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITÄT TÜBINGEN
Germany
Address
Markwiesenstr. 55
Reutlingen
UNIVERSITY OF GENEVA, MEDICAL FACULTY
Switzerland
Address
1, M.servet
Geneva
THE OPEN UNIVERSITY
United Kingdom
Address
Wallton Hall
Milton Keynes
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS ORGANIZATION
Spain
Address
Serrano 117
Madrid
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
Address
Carl-neuberg-str. 1
Hannover
INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY
Poland
Address
Ks.trojdena Str. 4
Warsaw
LUND UNIVERSITY
Sweden
Address
Paradisgatan 5C
117 Lund
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Address
Ecublans
Lausanne
UNIVERSITY OF HAIFA
Israel
Address
Mount Carmel
Haîfa
ENKAM PHARMACEUTICALS A/S
Denmark
Address
Fruebjergvej 3
Copenhagen
NEUROPHARMA S.A.U.
Spain
Address
Avenida De La Industria 52
Tres Cantos (Madrid)
REGLIA AB
Sweden
Address
Stena Center 1D
Göteborg
SCHAFER-N
Denmark
Address
Lersø Park Álle 42.6
Copenhagen
UNIVERSITY OF TARTU
Estonia
Address
18 Ylikooli Street
Tartu