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A new bio-sensor concept for medical diagnosis: targeted micro-bubbles and remote ultrasound transduction

Objective

The overall objective of TAMIRUT is to develop an innovative bio-sensor concept devoted to advanced medical diagnosis, in which the biological material is carried by targeted micro-bubbles injected inside the body and the transducer is remote. The remote transducer operates on the basis of the ultrasound response of such micro-bubbles, gathered and processed by an improved version of an ultrasound medical scanner (UMS). Targeted micro-bubbles (similar to the generic micro-bubbles composing the contrast agents actually used in medical echography) are designed to bind only to a desired target region: a bio-conjugate ligand is attached to micro-bubble shells producing the adhesion of them to specific molecular signatures.

The project goal is to exploit targeted micro-bubbles as bio-sensors producing measurements that will significantly complement the ultrasound molecular imaging and improve the medical diagnosis potential. Among many potential medical applications, the case study that will be addressed in the TAMIRUT project concerns the early detection, the assessment of the micro-vessel density, and the correct staging and grading of the prostate cancer. Such tasks will be dramatically improved by developing appropriate targeted micro-bubbles (i.e. bubbles able to bind on the endothelium of the neo-vessels of such a cancer) and measuring their local concentrations by means of the novel bio-sensor.

In addition, the repetition over time of such a measurement could help in assessing the disease evolution, especially regarding the angiogenesis aspects. The main objective of this project will be pursued by a multidisciplinary, strictly joint development of all the bio-sensor components, taking into account the need to remotely interrogate targeted micro-bubbles. In turn, micro-bubbles and bioconjugate ligands will be refined and tuned taking into account the desires of the medical community in relation to the introduction of new bio-sensor and addressed case study.

Call for proposal

FP6-2004-IST-NMP-2
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Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

.ESAOTE SPA
Address
Viale Bianca Maria 25
Milano
Italy

Participants (9)

UNIVERSITEIT TWENTE
Netherlands
Address
Drienerlolaan 1
Enschede
BRACCO RESEARCH SA
Switzerland
Address
Route De La Galaise, 31
Plan-les-ouates
UNIVERSITA DEGLI STUDI DI GENOVA
Italy
Address
Via Balbi 5
Genova
VERMON SA
France
Address
Rue Du General Renault 180
Tours
MEDIZINISCHE UNIVERSITAET INNSBRUCK
Austria
Address
Christoph-probst Platz 1
Innsbruck
SIGNALGENERIX LTD
Cyprus
Address
Maximos Court, Block B, 3Rd Floor, Leontiou A
Limassol
ERASMUS MEDICAL CENTER ROTTERDAM
Netherlands
Address
Dr. Molewaterplein 50
Rotterdam
ESAOTE SPA
Italy
Address
Via Camperio 9
Milano
FRAUNHOFER GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
Address
Hansastrasse 27 C
Munchen