CORDIS
EU research results

CORDIS

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Psychobiology of posttraumatic stress disorder

Project information

Grant agreement ID: 509213

  • Start date

    1 October 2004

  • End date

    30 June 2008

Funded under:

FP6-INCO

  • Overall budget:

    € 1 296 869

  • EU contribution

    € 1 296 869

Coordinated by:

UNIVERSITY MEDICAL CENTER UTRECHT

Netherlands

Objective

Post-traumatic stress disorder (PTSD) is the most common war-related psychiatric disorder occurring among combat veterans and other people exposed to war-zone stress. Current opinion is that the best results in PTSD understanding, diagnosis and treatment could be achieved by integrating psychological, biological and pharmacotherapeutical approaches.General objective of this project is to better understand the psychobiological basis of PTSD. The study will focus on establishing multiple correlations of d ifferent PTSD subtypes with relevant psychological, biochemical, endocrinological, genetic, physiological and anthropometric parameters. Five groups of subjects will be studied: a) patients with war-zone related PTSD, b) patients with war-zone related PTS D in remission, c) war-zone exposed subjects without PTSD, d) healthy controls from Western Balkans and e) healty controls from Western Europe. Subjects in these groups will be male. Psychological assessment will be performed on four analogous groups of female subjects. Psychological assessments include psychometrics, neuropsychological testing and personality assessment. Biological measurements will encompass parameters related to hypothalamo-pituitary-adrenocortical axis (including cortisol receptor a nd its gene polymorphism), anthropometry, body composition, lipid status, insulin resistance, and sleep disturbances. This study will yield new knowledge on relations between: a) basic psychological variables and PTSD, b) biological variables and PTSD, a nd c) biological and basic psychological variables in health and in PTSD. In addition, the foreseen benefits of the project include: d) development of combined psycho-biological batteries for PTSD screening, diagnosing and risk factors assessing, e) impr ovement of psychological instruments for measuring PTSD, and f) implementation of new biological markers for PTSD

Coordinator

UNIVERSITY MEDICAL CENTER UTRECHT

Address

Heidelberglaan 100
Utrecht

Netherlands

Participants (8)

INSTITUTE FOR BIOLOGICAL RESEARCH "SINISA STANKOVIC"

INSTITUTE OF ENDOCRINOLOGY, DIABETES & METABOLIC DISEASE

INTERNATIONAL AID NETWORK

MILITARY MEDICAL ACADEMY

QUEEN MARY AND WESTFIELD COLLEGE, UNIVERSITY OF LONDON

United Kingdom

SCHOOL OF MEDICINE UNIVERSITY OF RIJEKA

Croatia

SPECIALIZATION SCHOOL OF PSYCHIATRY - DEPARTEMENT OF NEUROLOGY AND PSYCHIATRIC SCIENCES - UNIVERSITY OF BARI - ITALY

Italy

VINCA INSTITUTE OF NUCLEAR SCIENCES

Project information

Grant agreement ID: 509213

  • Start date

    1 October 2004

  • End date

    30 June 2008

Funded under:

FP6-INCO

  • Overall budget:

    € 1 296 869

  • EU contribution

    € 1 296 869

Coordinated by:

UNIVERSITY MEDICAL CENTER UTRECHT

Netherlands