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Advances in hearing science : from functional genomics to therapies

Advances in hearing science : from functional genomics to therapies

Objective

EuroHear has two closely inter-related objectives.These are (1 )to provide fundamental knowledge about the development and function of the inner ear,and (2) to identify the molecular defects underlying hereditary hearing impairments (HI), including presbycusis,one of the most frequent forms of HI.Achieving these objectives will facilitate the development of therapies for alleviating HI.In order to address the above issues, the EuroHear project is organised into 4 components: 1-The identification of genes underlying sensorineural HI in humans and mice. 2-The analysis of the molecular and cellular mechanisms underlying the development and function of: "The hair bundle "The ribbon synapses of the hair cell and outer hair cell electromotility. "The ion channels, ion transporters and gap junction channels that contribute to the potassium homeostasis. 3-The standardisation, implementation and development of technologies. 4-The development of new tools for preventing and curing HI. Currently, we identify a multidisciplinary approach as the sina qua non condition for further progress in understanding the inner ear.The EuroHear consortium comprises a group of laboratories that are world experts in a variety of hearing research fields.EuroHear is a continuation and extension of a previous European consortium that has successively tackled early-onset,Mendelian forms of deafness and hearing loss.The success of this European consortium,which has identified half of the 37 known genes for isolated forms of HI in humans,has been due in large part to intense collaboration between human and mouse geneticists.Expected contributions of EuroHear include a standardisation of investigative protocols, the provision of access to large-scale platforms for genetics and genomic analysis,the development and diffusion of physiological and biophysical techniques of relevance for functional investigations of the inner ear,the creation of a variety of mouse

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Coordinator

INSTITUT DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac
Paris

France

Administrative Contact

Christine PETIT (Prof.)

Participants (28)

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UNIVERSITY COLLEGE LONDON

United Kingdom

TEL AVIV UNIVERSITY

Israel

MEDICAL RESEARCH COUNCIL

United Kingdom

STICHTING KATHOLIEKE UNIVERSITEIT, UNIVERSITY MEDICAL CENTRE NIJMEGEN

Netherlands

UNIVERSITATSKLINIKUM FREIBURG

Germany

MAX PLANCK SOCIETY FOR THE ADVANCEMENT OF SCIENCE, REPRESENTED BY THE MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS

Germany

ZENTRUM FUR MOLEKULARE NEUROBIOLOGIE, UNIVERSITAT HAMBURG

Germany

UNIVERSITY OF SUSSEX

United Kingdom

UNIVERSITATSKLINIKUM BONN

Germany

COMMISSARIAT A L'ENERGIE ATOMIQUE

France

ISTITUTO VENETO DI MEDICINA MOLECOLARE - CENTRO DI RICERCA DELLA FONDAZIONE PER LA RICERCA BIOMEDICAL

Italy

FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL

Spain

UNIVERSITATSMEDIZIN GOTTINGEN - GEORG-AUGUST-UNIVERSITAT GOTTINGEN - STIFTUNG OFFENTLICHEN RECHTS

Germany

UNIVERSITY OF HELSINKI - HELSINGIN YLIOPISTO

Finland

LNSTITUT CURIE, DIVISION DE RECHERCHE

France

GENOME RESEARCH LIMITED

United Kingdom

KAROLINSKA INSTITUTET

Sweden

UNIVERSITEIT ANTWERPEN

Belgium

INSTITUTE OF EXPERIMENTAL MEDICINE, HUNGARIAN ACADEMY OF SCIENCES

Hungary

ACREO AB

Sweden

INTEGRAGEN SA

France

AFFICHEM

France

INSERM TRANSFERT SA

France

UNIVERSITY OF SFAX FOR THE SOUTH

Tunisia

INSTITUTE OF GENETICS UNIVERSITY OF BONN

Germany

UNIVERSITY HOSPITAL OF THE UNIVERSITY OF COLOGNE

Germany

MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN

Germany

PHILIPPS-UNIVERSITAT MARBURG

Germany

Project information

Grant agreement ID: 512063

  • Start date

    1 December 2004

  • End date

    30 November 2009

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 15 212 824

  • EU contribution

    € 12 499 999

Coordinated by:

INSTITUT DE LA SANTE ET DE LA RECHERCHE MEDICALE

France