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Reprogramming the immune System for the Establishment of Tolerance

Objective

Transplantation dramatically improves the survival of patients with end-stage failure of vital organs. However, as a directconsequence of the immunosuppressive drugs permanently required to prevent rejection, recipients have a significantly increased risk of infection and malignancies. Moreover, these drugs are expensive, do not prevent long-term damage of the graft, and exert toxic effects outside the immune system. The induction of transplant tolerance, defined as permanent acceptance of the graft in absence of continuous immunosuppression, would be a major step forward. Recent advances in post-genomic immunology suggest that this goal is achievable in a near future. Indeed, new biotechnology products have been shown to promote long-term transplant acceptance in pre-clinical models. RISET will focus on the translation of these advances into industrial development and clinical practice. First, diagnostic tests to identify transplanted patients for whom immunosuppressive treatment could be safely minimized or withdrawn will be developed. These tests will be applied to patients under conventional treatment as well as to patients enrolled in pilot clinical investigations based on cellular products with potential for tolerance induction. Because of the nature of this research, effective communication with patient organizations and regulatory bodies will be organized, and related ethical and societal questions will be specifically addressed. In parallel, relevant models of tolerance will be used to identify new genes, molecules or cell types that will form the basis for novel diagnostics and therapeutic approaches. The exploitation of the knowledge created in RISET will be facilitated by the building of an industrial platform. In order to exploit innovative concepts emerging outside the consortium, RISET will be open to new industrial or academic partners for which a budget has been provisioned. An external advisory board will monitor the progress.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

IP - Integrated Project

Coordinator

UNIVERSITE LIBRE DE BRUXELLES
Address
Avenue Franklin Roosevelt 50
Bruxelles
Belgium

Participants (25)

UNIVERSITAET BERN
Switzerland
Address
Hochschulstrasse, 4
Bern
BLASTICON BIOTECHNOLOGISCHE FORSCHUNG GMBH
Germany
Address
Feldstr 10-12
5114 Kiel
DEUTSCHES KREBSFORSCHUNGSZENTRUM
Germany
Address
Im Neuenheimer Feld 280
10 19 49 Heidelberg
KING'S COLLEGE LONDON
United Kingdom
Address
Strand
London
LNSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
101 Rue De Tolbiac
Paris
CENTRE HOSPITALIER DE NANTES
France
Address
5 Allee De L'ile Gloriette'
Nantes
LNSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE
Czechia
Address
Videnska 1958/9
Prague 4
LEIDEN UNIVERSITY MEDICAL CENTER
Netherlands
Address
Albinusdreef 2, 2333 Za
9600 Leiden
MEMOREC BIOTEC GMBH
Germany
Address
Stoeckheimer Weg 1
Cologne
CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
Address
Via Olgettina 60
Milan
TCLAND EXPRESSION
France
Address
30 Bd Jean Monnet
Nantes
UNIVERSITE RENE DESCARTES - PARIS V
France
Address
Rue De Vaugirard 156
Paris
UNIVERSITY OF SCHLESWIG-HOLSTEIN
Germany
Address
Schittenhelmstr. 12
Kiel
CENTRO NACIONAL DE TRASPLANTES Y MEDICINA REGENERATIVA - ONT
Spain
Address
Sinesio Delgado 8
Madrid
WEIZMANN LNSTITUTE OF SCIENCE
Israel
Address
2 Herzel Street
Rehovot
UNIVERSITY OF KONSTANZ
Germany
Address
Universitaetsstr. 10
Konstanz
PROIMMUNE LIMITED
United Kingdom
Address
Magdalen Centre, Oxford Science Park, Oxford Ox4 4Ga
Oxford
HENOGEN S.A.
Belgium
Address
Rue Des Professeurs Jeener Et Brachet, 12
Gosselies
MILTENYI BIOTEC GMBH-MACSMOLECULAR BUSINESS UNIT
Germany
Address
Stoeckheimer Weg 1
Cologne
KLINIKUM DER UNIVERSITAET REGENSBURG
Germany
Address
Franz Josef Strauss Allee 11
Regensburg
INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI-SUNYER
Spain
Address
Villarroel 170
n/a Barcelona
ACADEMIC MEDICAL CENTER
Netherlands
Address
Meidbergdreef 9, 1105 Az
22660 Amsterdam
FUNDACION PRIVADA INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Spain
Address
Gran Via Km 2,7
Hospitalet De Ll. (Barcelona)
CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN
Germany
Address
Schumannstrasse, 20-21
Berlin