Objective High resolution ¡maging of living cells and subcellular components is essential for functional and structural genomics'. Scanning Probe Microscopy (SPM) has evolved into the imaging method of choice that yields the greatest structural details on biological samples such as proteins, nucleotides, membranes and cells in their native, aqueous environment and at ambient conditions. In addition, due to its high lateral resolution and sensitive force detection capability, the exciting possibility of measuring inte r- and intra-molecular forces of bio-molecules on the single molecule level has become possible, leading to new possibilities for the evolution of methods that will enable us to examine the physiological consequences of, even, the interaction of a single l igand molecule with its cognate receptor. In this project we propose to develop Scanning Probe Microscopy to advance the state of the art of this technique. With the support of the Sixth Framework program, Scanning Probe Microscopy is ready to become a mat ure imaging and measurement platform for cell biology that will become as widespread in the biomedicai laboratory as the confocal microscope, adding value to the European scientific instrument market and giving it a major presence worldwide.' Fields of science natural sciencesbiological sciencescell biologynatural sciencesphysical sciencesclassical mechanicsfluid mechanicsfluid staticsnatural sciencesbiological sciencesgeneticsnucleotidesnatural sciencesphysical sciencesopticsmicroscopyconfocal microscopynatural sciencesbiological sciencesgeneticschromosomes Keywords Force Microscopy Scanning Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms LSH-2003-1.1.2-2 - Structure determination of large protein complexes Call for proposal FP6-2003-LIFESCIHEALTH-I See other projects for this call Funding Scheme NoE - Network of Excellence Coordinator UNIVERSITEIT LEIDEN EU contribution No data Address Rapenburg 70 Leiden Netherlands See on map Links Website Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITY COLLEGE LONDON United Kingdom EU contribution No data Address Gower street London See on map Links Website Opens in new window Total cost No data WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution No data Address Herzelstreet 2 Rehovot See on map Links Website Opens in new window Total cost No data UNIVERSITY OF BRISTOL United Kingdom EU contribution No data Address Senate house, tyndall avenue Bristol See on map Links Website Opens in new window Total cost No data JPK INSTRUMENTS AG Germany EU contribution No data Address Bouchéstrasse 12, haus 8, aufgang b Berlin See on map Links Website Opens in new window Total cost No data SCIENTEC France EU contribution No data Address 2 allee de garays zae des glaises Palaiseau See on map Links Website Opens in new window Total cost No data LEIDEN PROBE MICROSCOPY Netherlands EU contribution No data Address Niels bohrweg 2 Leiden See on map Links Website Opens in new window Total cost No data AGILENT TECHNOLOGIES ÖSTENRREICH GMBH Austria EU contribution No data Address Dresdner strasse 81-85 Vienna See on map Links Website Opens in new window Total cost No data JOHANNES KEPLER UNIVERSITÄT LINZ Austria EU contribution No data Address Altenbergerstr. 69 Linz See on map Links Website Opens in new window Total cost No data WESTFÄLISCHE WILHELMS UNIVERSITÄT MÜNSTER Germany EU contribution No data Address Schlossplatz 2 Muenster See on map Links Website Opens in new window Total cost No data