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DNA damage response and repair mechanisms

Objective

This integrated project focuses on unravelling mechanisms of DNA damage response and repair, an area with a major impact on human health, notably cancer, immunodeficiency, other ageing related-diseases and inborn disorders. The proposal brings together le ading groups with multi-disciplinary and complementary expertise to cover all pathways impinging upon genome stability, ranging from molecules to mouse models and human disease. Objectives: The main objective is to obtain an integrated perception of the in dividual mechanisms, their complex interplay and biological impact, using approaches ranging from structural biology to systems biology. Translation of the results that we obtain is expected to contribute to an improved quality of life through (1) possible identification of genetic markers for assessment of susceptibility to occupational hazards and disease, (2) discovery of promising targets for therapy, (3) improved diagnostic and prognostic procedures for genetic disorders, (4) early diagnosis and preven tion of cancer and other ageing-related diseases. We have also included a strong training component in the project to invest in young talented students, who may become the leaders of tomorrow. Approach: The pleiotropic effects inherent to the time-dependen t erosion of the genome and the complexity of the cellular responses to DNA damage necessitate a comprehensive, multi-disciplinary approach, which ranges from molecule to patient. At the level of structural biology and biochemistry, individual components a nd pathways will be analysed to identify new components and clarify reaction mechanisms. The interplay between pathways and cross-talk with other cellular processes will be explored using both biochemical and cellular assays. To better understand the funct ion and impact of DNA damage response and repair systems in living organisms, we will take full advantage of our existing unique and extensive collection of models #

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

IP - Integrated Project

Coordinator

ERASMUS MC
Address
Dr. Molewaterplein 50
Rotterdam
Netherlands

Participants (14)

CANCER RESEARCH UK
United Kingdom
Address
61 Lincoln's Inn Fields'
London
CENTRE EUROPEEN POUR LA RECHERCHE EN BIOLOGIE ET MEDECINE
France
Address
1 Rue Laurent Fries
Illkrich
DANISH CANCER SOCIETY
Denmark
Address
Strandboulevarden 49
Copenhagen
IFOM, ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Italy
Address
Via Adamello, 16
Milan
KUDOS PHARMACEUTICAL LIMITED
United Kingdom
Address
327 Cambridge Science Park, Milton Road
Cambridge
LEIDEN UNIVERSITY MEDICAL CENTER, DIVISION 5
Netherlands
Address
Wassenaarseweg 72
Leiden
LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN
Germany
Address
Geschwister-scholl-platz 1
Munich
NATIONAL UNIVERSITY OF IRELAND, GALWAY
Ireland
Address
University Road
Galway
NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY
Norway
Address
Hovedbygningen, Gloshaugen, Hogskoleringen 1
Trondheim
RIKSHOSPITALET-RADIUMHOSPITALET HF
Norway
Address
Sognsvannsvn. 20
Oslo
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge
UNIVERSITA' DEGLI STUDI DI MILANO
Italy
Address
Via Festa Del Perdono 7
Milano
UNIVERSITY OF SUSSEX
United Kingdom
Address
Sussex House
Falmer, Brighton
UNIVERSITY OF ZURICH
Switzerland
Address
Rämistrasse 71
Zurich