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Beta cell programming for treatment of diabetes

Objective

Diabetes is a frequent chronic disease that reduces quality of life and increases risks for life-threatening complications. Its onset in younger patients is caused by massive losses in insulin-producing beta cells. Regenerating a functional beta cell mass is thus a major goal in biomedicine and in society. Beta cell grafts prepared from human pancreases can cure the disease but development of this form of beta cell therapy is hindered by shortage in donor organs. Our consortium with leading teams in molecul ar, developmental and functional biology has worked out an integrated program to generate insulin-producing beta cells in therapeutic quantities and established interactions to translate knowledge to associated bioindustry and multicenter clinical trials, as well as to society. Nature's biologic program to develop and preserve a functional beta cell mass throughout life is taken as platform for directing strategies towards laboratory production of a therapeutic beta cell mass. Beta cells will be derived fro m embryonic stem cells and from transdifferentiating liver, intestinal and pancreatic exocrine cells. Functional genomics will be used to compare phenotypes of beta cells from new sources with those isolated from the pancreas. This analysis will direct fur ther research and judge on the start of preclinical testing. It will also generate new tools and quality control criteria that will allow standardization of ongoing trials and adjustments in graft biology to increase its long-term survival and function in patients. The consortium considers its plan realistic in its perspective to help develop a cure for diabetes by (re)programming cells for beta cell therapy.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

IP - Integrated Project

Coordinator

VRIJE UNIVERSITEIT BRUSSEL
Address
Pleinlaan 2
Brussels
Belgium

Participants (23)

CHRISTIAN DE DUVE INSTITUTE OF CELLULAR PATHOLOGY
Belgium
Address
Avenue Hippocrate 75/75.50
Brussels
UNIVERSITY OF COPENHAGEN
Denmark
Address
Norregade 10
Copenhagen
TEL AVIV UNIVERSITY
Israel
Address
Ramat Aviv
Tel Aviv
UNIVERSITAT AUTONOMA DE BARCELONA
Spain
Address
Campus Universitari Uab
Bellaterra (Cerdanyola Del Vallès)
LUND UNIVERSITY
Sweden
Address
Paradisgarten 5C
Lund
UNIVERSITY OF BATH
United Kingdom
Address
Claverton Down
Bath
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London
JDRF CENTER FOR BETA CELL THERAPY IN DIABETES VZW
Belgium
Address
Laarbeeklaan 103
Brussels
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
3 Rue Michel Ange
Paris
INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
Address
Villarroel 170
Barcelona
BETA-CELL NV
Belgium
Address
Kranenberg 6
Zellik
THROMB-X NV
Belgium
Address
Herestraat 49
Louvain
NOVO NORDISK A/S
Denmark
Address
Novo Alle
Bagsvaerd
CELLARTIS
Sweden
Address
Arvid Wallgrens Backe 20
Gothenburg
COPENHAGEN UNIVERSITY HOSPITAL RIGSHOSPITALET
Denmark
Address
Blegdamsvej 9
Copenhagen
UNIVERSITAIR ZIEKENHUIS BRUSSEL
Belgium
Address
Laarbeeklaan 101
Brussels
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
Address
The Authority For Research And Development, Edmond J. Safra Campus, Givat Ram
Jerusalem
CENTRE EUROPÉEN DE RECHERCHE EN BIOLOGIE ET MÉDECINE
France
Address
1 Rue Laurent Fries
Illkirch
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Address
Batiment Ce 3316 Station 1
1015 Lausanne
FACULTÉ DE MEDECINE, UNIVERSITÉ DE GENÈVE
Switzerland
Address
Rue Michel-servet, 1
Geneva
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101 Rue De Tolbiac
Paris
UNIVERSITY OF LIÈGE
Belgium
Address
Place Du Xx Août, 7
Liège
UNIVERSITÀ DEGLI STUDI DI PERUGIA
Italy
Address
Piazza Dell'università, 1
Perugia