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Genetics of Sepsis in Europe

Objective

GenOSept is a specific targeted research project (STREP) which uses a multidisciplinary fundamental genomics approach (gene expression, structural genomics, population genetics) to examine genetic predisposition to sepsis. Sepsis (life-threatening infection) is a major public health problem throughout Europe. In the USA in 1995 it cost $17 billion to treat 751,000 patients with severe sepsis, of whom 28.6% died. The Center for Disease Control suggests that sepsis-attributable mortality rates are rising. We hypothesize that susceptibility to expensive new treatments, and fatal outcomes from severe sepsis, are in part, genetically determined. GenOSept work packages will test this hypothesis using the following approach. We will use gene expression studies to define novel candidate genes including those controlling programmed cell death. The novel candidate genes so identified will then be analysed in subsequent epidemiologic studies of genetic predisposition to sepsis-related mortality and morbidity in European intensive care units. The European Society of Intensive Care Medicine (ESICM) will co-ordinate a consortium of leading experts in sepsis, genomics, genetic epidemiology, biometrics and genetic high-throughput genotyping to link this new science to patient-centred outcomes. GenOSept will provide important data on gender-related mortality and morbidity. It will have a major impact on diagnosis and treatment of European sepsis patients in subsequent therapeutic trials by targeting risk subpopulations and focussing expensive new treatments. GenOSept will standardise protocols for genotyping, facilitate application of new knowledge in functional and structural genomics, harmonize high-throughput genotyping and quality control between major European centres, and contribute to reducing sepsis-related mortality in European health care.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

EUROPEAN SOCIETY OF INTENSIVE CARE MEDICINE
Address
Avenue Joseph Wybran 40
Brussels
Belgium

Participants (13)

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÂT BONN
Germany
Address
Regina-pacis-weg 3
Bonn
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
2 Ter Rue D'alésia
Paris
CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
UNIVERSITA DEGLI STUDI DI TORINO
Italy
Address
Via Verdi 8
Torino
UNIVERSITY ROVIRA & VIRGILI - HOSPITAL UNIVERSITARI JOAN XXIII
Spain
Address
Carrer Dr Mallafre Guasch 4
Tarragona
GSF NATIONAL RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Germany
Address
Ingolstädter Landstr. 1
1129 Neuherberg
HADASSAH MEDICAL ORGANISATION
Israel
Address
Kiryat Hadasah
12000 Jerusalem
SIRS-LAB GMBH
Germany
Address
Winzerlaer Strasse 2
Jena
UNIVERSITY ULM, MEDICAL FACULTY
Germany
Address
Steinhövelstrasse 5
Ulm
KLINIKUM DER FRIEDRICH-SCHILLER-UNIVERSITÄT JENA
Germany
Address
Bachstr. 18
Jena
MASARYK UNIVERSITY BRNO, MEDICAL FACULTY
Czechia
Address
Zerotinovo Nam.9
Brno
NATIONAL MEDICAL CENTER
Hungary
Address
Szabolcs U. 33-35
Budapest
TARTU UNIVERSITY CLINICS
Estonia
Address
L. Puusepa 8
Tartu