CORDIS
EU research results

CORDIS

English EN

Innovative diagnostic tools and therapeutic approaches for dengue disease

Project information

Grant agreement ID: 517711

  • Start date

    1 November 2005

  • End date

    30 April 2009

Funded under:

FP6-INCO

  • Overall budget:

    € 2 682 000

  • EU contribution

    € 2 550 000

Coordinated by:

INSTITUT PASTEUR DE PARIS

France

Objective

The main aim of the DENFRAME project is to improve the management of dengue disease in the human populations of Latin America and Asia. Dengue has emerged as the most important vector-borne viral disease in tropical areas. Epidemics with a high frequency of a severe, life-threatening illness known as dengue hemorrhagic fever continue to expand geographically. Despite the increased health and economic impact of dengue, there are as yet no specific preventive or therapeutic interventions. There is an urgent need for reliable rapid diagnostic and new therapeutic tools for people at risk of DV infection. The Consortium will be constituted of 13 partners based in Asia (4), Europe (5) and Latin America (4). Our project will include 2 complementary workprogrammes: the first one concentrates on the standardization and validation of the current diagnostic assays, the development of new diagnostic tools (biosensor technology) and the implementation of procedures to validate them. A key component of this workprogramm e is the collection of field strains of DV associated with well-characterized clinical data and biological samples. The second workprogramme aims to develop an integrated approach towards understanding the DV-host interaction that focuses on key componen ts of innate immunity to DV infection and to identify potential therapeutic agents (small molecule inhibitors). To identify lead compounds with anti-DV activity, 2 existing libraries will be used for screening: one based in Europe and one based in Asia ( compounds isolated from the Chinese Traditional Medicine). The tasks will be carried out by the concerted efforts of the different groups with complementary skills and experience. This multidisciplinary strategy will establish the framework to implement ne w diagnostic tools and test future therapeutic molecules, and represents a critical new collaborative approach that will underpin on-going efforts to combat this major public health problem.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

INSTITUT PASTEUR DE PARIS

Address

28, Rue Du Docteur Roux
Paris

France

Participants (12)

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

BEN GURION UNIVERSITY OF THE NEGEV

Israel

BERNHARD NOCHT INSTITUTE OF TROPICAL MEDICINE

Germany

UNIVERSITY COLLEGE LONDON

United Kingdom

FUNDACION INSTITUTO LELOIR

Argentina

INSTITUTO EVANDRO CHAGAS/SVS/MS

Brazil

INSTITUT PASTEUR DE LA GUYANE

France

CENTRO DE INVESTIGACION Y ESTUDOS AVANZADOS

Mexico

INSTITUT PASTEUR DU CAMBODGE

Cambodia

SHANGHAI INSTITUTE OF MATERIA MEDICA

China

HONG KONG UNIVERSITY - PASTEUR RESEARCH CENTRE LIMITED

Hong Kong

INSTITUT PASTEUR DE HO CHI MINH VILLE

Vietnam

Project information

Grant agreement ID: 517711

  • Start date

    1 November 2005

  • End date

    30 April 2009

Funded under:

FP6-INCO

  • Overall budget:

    € 2 682 000

  • EU contribution

    € 2 550 000

Coordinated by:

INSTITUT PASTEUR DE PARIS

France