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ENFIN - an experimental network for functional integration

ENFIN - an experimental network for functional integration

Objective

We propose to form a Network of Excellence in the area of bioinformatics to provide a Europe-wide integration of computational approaches in systems biology. This network will be focused on the development and critical assessment of computational approaches in this area, but uniquely will bring together a range of backgrounds and laboratory contexts that will span investigative computer science through to traditional wet-bench molecular biology. Despite the progress in bioinformatics methods and databases, even the best experimental labs use. only a small number of computational tools in their work and rarely exploit the potential of multiple datasets. This network will enable a transformation of the way computational analysis is used in the laboratory and the infrastructure will be entirely open, analogous to the genome information. To achieve its goals, the network will internally have close collaboration between experimental and computational research, with a specific consumables budget for experimentally testing predictions. The computational work includes the development of a distributed database infrastructure appropriate for small laboratories and development of analysis methods including Bayesian networks, metabolite flux modeling and correlations of protein modifications to pathways. The experimental techniques used to test this system include mass spectroscopy, synthetic peptide biochemistry and RNAi knockdown. Where appropriate we have chosen experimental areas connected to intracellular signaling associated with the cell cycle. An additional benefit will be greater understanding in this area. Overall the ENFIN network will deliver four main products: a platform for database provision of diverse biological data (the ENFIN core), a suite of analysis tools integrated with this platform (the ENFIN analysis layer), extensive documentation written from the wet laboratory perspective and "best practice" guidelines...

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Address

Meyerhostrasse 1
Heidelberg

Germany

Administrative Contact

Ewan BIRNEY (Dr)

Participants (22)

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UNIVERSITY OF DUNDEE

United Kingdom

TECHNICAL UNIVERSITY OF DENMARK

Denmark

UNIVERSITY OF ROME TOR VERGATA

Italy

MEDICAL RESEARCH COUNCIL

United Kingdom

LUDWIG INSTITUTE FOR CANCER RESEARCH

Sweden

HELSINGIN YLIOPISTO

Finland

UNIVERSITY COLLEGE LONDON

United Kingdom

CENTER FOR RESEARCH AND TECHNOLOGY, HELLAS

Greece

UNIVERSITAET ZU KOELN

Germany

WEIZMANN INSTITUTE OF SCIENCE

Israel

AS EGEEN

Estonia

SERONO PHARMACEUTICAL RESEARCH INSTITUTE (SPRI), A DIVISION OF SERONO INTL. S.A. (SERONO INTERNATIONAL SA)

Switzerland

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLÃ?GICAS CARLOS III

Spain

TECHNISCHE UNIVERSITAET CAROLO-WILHELMINA ZU BRAUNSCHWEIG

Germany

OÜ QURETEC

Estonia

COMMISSARIAT A L'ENERGIE ATOMIQUE

France

SWISS INSTITUTE OF BIOINFORMATICS

Switzerland

LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.

Switzerland

HUMBOLDT-UNIVERSITAET ZU BERLIN

Germany

UNIVERSITAET BASEL

Switzerland

MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV., REPRESENTED BY MAX PLANCK INSTITUTE OF BIOCHEMISTRY

Germany

Project information

Grant agreement ID: 518254

  • Start date

    15 November 2005

  • End date

    14 May 2011

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 8 967 500

  • EU contribution

    € 8 967 500

Coordinated by:

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany