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Focusing NMR on the machinery of Life

Focusing NMR on the machinery of Life

Objective

NMR has established itself as an invaluable tool to investigate the structure and dynamics of biomolecules. Its contributions to the general area of Structural Genomics are expected to be even more widely appreciated, as i) weak interactions between biomol ecules are increasingly recognized as central to the biochemical processes of Life and ii) weak interactions are best grasped by NMR. Europe has a human and infrastructure capital in the field of NMR that is second to none. With this project we intend to p romote the networking and coordination of NMR research in Structural Genomics. The planned activities will include: organization of meetings, exchange of personnel, exchange of good practices, implementation of a virtual laboratory, distribution of an elec tronic newsletter. These activities will be framed by dividing the scientific arena in four broad topics defined as horizontal: a) protein-protein interactions; b) protein-DNA/RNA interactions; c) protein-ligand interactions; d) membrane and immobilized pr oteins. The objectives of the project will be further pursued through vertical topics (sample preparation, NMR methods, strategies to tackle high-molecular-weight systems, software tools) that are relevant for all the scientific areas a-d. The coordination of these researches will be achieved by establishing contacts among existing national and international projects and by providing a platform for exchanges among European researchers. Good practices and innovative procedures will be widely communicated in the virtual laboratory, and complemented by an electronic newsletter. Meetings will be organized in the above areas with the aim of keeping abreast of the progress of research and contributing new materials to the virtual lab. An annual general meeting wil l be organized in order to foster networking and coordination of the research. All activities will be open to European scientists not involved in this proposal or not directly working with NMR

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Coordinator

CONSORZIO INTERUNIVERSITARIO DI RISONANZE MAGNETICHE DI METALLOPROTEINE PARAMAGNETICHE

Address

Via Luigi Sacconi, 6
Sesto Fiorentino

Italy

Administrative Contact

Ivano BERTINI (Professor)

Participants (10)

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EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

UTRECHT UNIVERSITY

Netherlands

JOHANN WOLFGANG GOETHE-UNIVERSITY AM MAIN

Germany

MASARYKOVA UNIVERZITA V BRNO

Czechia

THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

GSF-NATIONAL RESEARCH CENTER FOR ENVIRONMENT AND HEALTH, GMBH

Germany

ECOLE NORMALE SUPÉRIEURE DE PARIS

France

FORSCHUNGSINSTITUT FÜR MOLEKULARE PHARMAKOLOGIE

Germany

KØBENHAVNS UNIVERSITET

Denmark

Project information

Grant agreement ID: 18758

  • Start date

    1 December 2005

  • End date

    28 February 2009

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 1 070 000

  • EU contribution

    € 1 070 000

Coordinated by:

CONSORZIO INTERUNIVERSITARIO DI RISONANZE MAGNETICHE DI METALLOPROTEINE PARAMAGNETICHE

Italy