Objectif Linkage studies of cancer families have identified high-penetrance cancer genes such as BRCA1 and BRCA2. However, although these genes have resulted in novel insights into cancer, it is clear that a large component of inherited cancer risk remains unacc ounted for. It has been proposed that common low penetrance cancer susceptibility genes contribute significantly to the genetic predisposition of cancer in a polygenic model of inheritance. Association studies have been suggested as the method of choic e for finding susceptibility alleles of high frequency but low penetrance. Here, we propose to take advantage of accumulating genomic data and two European populations of different history and structure to determine the contribution of candidate cancer susceptibility genes to different clinical forms of breast and prostate cancer. We will use a population based association study in Iceland and the Netherlands to map the risk profiles associated with common polymorphic variants in and near candidate c ancer susceptibility genes in breast and prostate cancer patients. We will also develop methods for statistical analysis of complex genomic data which can be used in this and other projects. The proposed study has the potential to cast light on how gen etic variants affect the risk of cancer initiation and how it affects progression and response to treatment. Finally, the results may serve as a starting point for building models of genetic risk of these cancers. Champ scientifique medical and health sciencesclinical medicineoncologyprostate cancermedical and health scienceshealth sciencespublic healthhumanitieshistory and archaeologyhistorymedical and health sciencesclinical medicineoncologybreast cancernatural sciencescomputer and information sciencescomputational science Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) LSH-2004-2.2.0-6 - Prevention, detection and treatment of familial cancers, such as cancer of the prostate, ovary, breast, colon and skin Appel à propositions FP6-2004-LIFESCIHEALTH-5 Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur ISLENSK ERFDAGREINING EHF (DECODE GENETICS EHF). Contribution de l’UE Aucune donnée Adresse Sturlugata 8 REYKJAVIK Islande Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITY OF AARHUS Danemark Contribution de l’UE Aucune donnée Adresse Nordre Ringgade 1 AARHUS Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Royaume-Uni Contribution de l’UE Aucune donnée Adresse University Offices, Wellington Square OXFORD Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY RADBOUD UNIVERSITY NIJMEGEN MEDICAL CENTRE Pays-Bas Contribution de l’UE Aucune donnée Adresse Geert Grooteplein Zuid 10 NIJMEGEN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée ICELAND GENOMICS CORPORATION/URDUR VERDANDI SKULD Islande Contribution de l’UE Aucune donnée Adresse Snorrabraut 60 REYKJAVIK Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée BIOINFORMATICS APS Danemark Contribution de l’UE Aucune donnée Adresse Hoegh-Gulbergsgade 10, Building 090 AARHUS Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
