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Neuroprotective strategies for multiple sclerosis

Objective

Despite intensive research on the causes and pathogenesis of multiple sclerosis (MS), the genetic basis of this common cause of neurological disability is still unknown and the complex immunopathological mechanisms underlying brain injury are only beginning to be understood. To date, no curative therapy is available and none of the existing drugs can stop the neurodegenerative process responsible for disease progression. The NeuroproMiSe project represents a highly focussed and integrated effort to investigate in depth the genetic and mechanistic pathways involved in inflammation-induced neurodegeneration, and exploit this knowledge to develop novel candidate drugs for effective neuroprotective therapy. NeuroproMiSe specific objectives are: 1) To identify the major genes and critical pathways associated with MS and inflammatory neurodegeneration. This goal will be achieved through a comparative genetic approach, using an established animal platform suitable for identification of EAE susceptibility genes, and well-characterized, ethnically homogeneous cohorts of MS patients. Through genomic and proteomic screens carried out in animal disease models, further knowledge will be obtained on genes and molecular pathways involved in inflammatory neurodegeneration. 2) To elucidate essential immunopathological mechanisms of neurodegeneration, focussing on innate and adaptive immune responses and on the use of humanized animal models to define new rational ways of developing disease modifying drugs. 3) To develop novel neuroprotective drugs based on targets validated in animal models. In a first step, new therapeutics targeting critical pathways (Ncf-1, TREM-2, TNFR subtypes, ion channels, glutamate receptors, apoptosis) identified by the applicants will be tested and used in combination therapies. The project is conducted in alliance with four SMEs and has potential for direct transfer of basic research results into clinical studies and economic and society benefits.

Call for proposal

FP6-2004-LIFESCIHEALTH-5
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

ISTITUTO SUPERIORE DI SANITÀ
Address
Viale Regina Elena 299
Rome
Italy

Participants (24)

UNIVERSITÄTSMEDIZIN GÖTTINGEN - GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN - STIFTUNG ÖFFENTLICHEN RECHTS
Germany
Address
Robert-koch-str. 40
Goettingen
LUNDS UNIVERSITET
Sweden
Address
Paradisgatan 5
117 Lund
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
Park Crescent, 20
London
MEDICAL UNIVERSITY OF VIENNA
Austria
Address
Spitalgasse 23
Vienna
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
Rue De Tolbiac, 101
Paris
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Hofgartenstrasse 8
Muenchen
KAROLINSKA INSTITUTET
Sweden
Address
Nobels Väg 5
Stockholm
TERVEYDEN JA HYVINVOINNIN LAITOS - NATIONAL LNSTITUTE FOR HEALTH AND WELFARE
Finland
Address
Mannerheimintie 166
Helsinki
UNIVERSITY OF SOUTHAMPTON
United Kingdom
Address
University Road, Highfield
Southampton
KING'S COLLEGE, LONDON
United Kingdom
Address
Strand
London
UNIVERSITY OF STUTTGART - UNIVERSITÄT STUTTGART
Germany
Address
Keplerstrasse 7
Stuttgart
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
Address
Broerstraat 5
Groningen
HELLENIC PASTEUR INSTITUTE
Greece
Address
Vassilissis Sophias Avenue
Athens
HYCULT BIOTECHNOLOGY B.V.
Netherlands
Address
Fronstraat 2A, 5405 Pb
Uden
EISAI LONDON RESEARCH LABORATORIES LTD.
United Kingdom
Address
Bernard Katz Building, University College London, Gower Street
London
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN
Germany
Address
Regina Pacis Weg 3
Bonn
DIREVO BIOTECH AG
Germany
Address
Nattermannallee 1
Cologne (Köln)
BIOVITRUM AB
Sweden
Address
Berzelius Väg 8
Stockholm
CELONIC GMBH
Germany
Address
Karl-heinz-beckurts-str. 13
Juelich
REDOXIS AB
Sweden
Address
Arvid Walllgrens Backe 20
Göteborg
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Queen Square
London
UNIVERSITAET DES SAARLANDES
Germany
Address

151150 Saarbruecken
FONDAZIONE SANTA LUCIA
Italy
Address
Via Ardeatina, 306
Roma
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford