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Consortium for Research into Nuclear Receptors in Development and Aging

Objective

Nuclear receptors function throughout development and aging as molecular integrators of complex physiological regulations, such as growth, reproduction and metabolism. To translate genetic knowledge from the Human Genome into therapy requires intimate understanding of fundamental regulatory mechanisms. CRESCENDO will build on existing knowledge and infrastructures by drawing together European excellence to focus on signalling dynamics, integration of target gene responses during development and aging, and human genetics and pathophysiology, emphasising key nuclear receptors. State-of-the-art genomic and post-genomic techniques will lever advances on mechanisms and kinetics of nuclear receptor signalling in processes underlying development and aging. Information on spatial and temporal aspects of signalling dynamics will feed into a broader vision of how nuclear receptors integrate multiple inputs in whole organisms across the life span. Focus will be on developmental targets, on brain development and aging, and the complex interplay between metabolism, particularly glucose and lipid signalling, and brain function. The brain is emphasised, as its disorders often cause most distress in unhealthy aging. A strong investment in bioinformatics will facilitate data extraction from multi-level analyses (genes to cells to organisms) and accelerate determination of targets, regulatory networks and integration of physiological responses within individuals and populations. The consortium includes molecular and developmental biologists, physiologists and human geneticists, and has access to major national and transnational data banks and resources. Nuclear receptor research is being revolutionised by the combination of technological advances with novel insights into signalling processes. CRESCENDO will ensure that European research in the field accelerates its momentum, fulfilling its potential to catalyse therapeutic innovation and to create substantial socio-economic benefit.

Call for proposal

FP6-2004-LIFESCIHEALTH-5
See other projects for this call

Funding Scheme

IP - Integrated Project
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Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Address
3 Rue Michel Ange
Paris
France

Participants (20)

KAROLINSKA INSTITUTET
Sweden
Address
Nobelsväg 5
Stockholm
HELSINGIN YLIOPISTO
Finland
Address
Yliopistonkatu 4
Helsingin Yliopisto, Helsinki
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstr. 1
Heidelberg
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFT E.V. REPRESENTED BY MAX PLANCK INSTITUTE OF PSYCHIATRY
Germany
Address
Hofgartenstrasse 8
Munich
UNIVERSITY OF MILAN
Italy
Address
Via Festa Del Perdono, 7
Milan
UNIVERSITY OF GENEVA
Switzerland
Address
24, Rue Du Général Dufour
Geneva 4
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Serrano 117
Madrid
INSTITUTE OF MOLECULAR GENETICS - ACADEMY OF SCIENCES OF THE CZECH REPUBLIC - V.V.I
Czechia
Address
Videnska 1083
Prague 4
UNIVERSITY OF OSLO
Norway
Address
Problemveien 5-7
1046 Blindern Oslo
HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT, GMBH
Germany
Address
Ingolstädter Landstraße 1
Neuherberg
STAZIONE ZOOLOGICA ANTON DOHRN
Italy
Address
Villa Comunale
Napoli
DEUTSCHES KREBSFORSCHUNGSZENTRUM
Germany
Address
Im Neuenheimer Feld 280
Heidelberg
CENTRE EUROPÉEN DE RECHERCHE EN BIOLOGIE ET MÉDECINE - GROUPEMENT D'INTÉRÊT ECONOMIQUE
France
Address
1 Rue Laurent Fries
10142 Illkirch
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101 Rue De Tolbiac
Paris
SERVIER RESEARCH INSTITUT
France
Address
3 Rue De La Republique
Suresnes
KARO BIO AB
Sweden
Address
Hälsovägen 7
Novum Huddinge
SECONDA UNIVERSITÀ DEGLI STUDI DI NAPOLI
Italy
Address
Viale Beneduce N. 10
Caserta
GENOME INSTITUTE OF SINGAPORE
Singapore
Address
60 Biopolis Street #02-01 Genome Building
Singapore
UNIVERSITÉ DE LAUSANNE
Switzerland
Address
Quartier Unil-centre, Bâtiment Unicentre
Lausanne
AXCENTUA PHARMACEUTICALS AB
Sweden
Address
Nobels Allé 10
Huddinge