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The role of chronic INfections in the development of CAncer

Objective

Approximately 17% of human cancer cases occurring world-wide are caused by one of 6 human viruses, Human papillomavirus (HPV), Epstein Barr virus (EBV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human herpesvirus 8 (HHV8; Kaposi´s sarcoma herpesvir us) and Human T- cell leukemia virus I (HTLV-I). In addition, the bacterium Helicobacter pylori is the infectious agent responsible for the second highest number of infection-associated cancers and additional infectious etiologies of cancer are likely to e xist. The INCA Integrated Project aims towards a better understanding of (1) the molecular and cellular circuits involved in the development of cancers caused by these infectious agents, (2) the mechanisms of long-term persistence of these infectious agent s in apparently healthy hosts, and (3) which genetic factors contribute to cancer development. Based on this knowledge INCA will develop and validate (4) animal models to study chronic inflammation and cancer progression, and (5) new diagnostic procedures for the identification of infected individuals likely to develop infection-associated malignancies. This will ultimately lead to (6) the identification of new drugs and procedures to interfere with processes that are central to the development of infection -associated cancer. The results of this joint effort will contribute to our understanding of malignant transformation and provide us with new tools to address an urgent socio-economic and human need. The INCA consortium will take a multi-disciplinary appro ach to the realisation of these goals and brings together scientists including SMEs from different backgrounds, who will work at all levels of a prevention and therapy-oriented process. The organisation of the research themes and joint activities in INCA s ubprojects will ensure the rapid spread of new findings into the entire programme. Professional management will promote efficient integration, realisation of scientific objectives & knowledge dissemination.

Call for proposal

FP6-2004-LIFESCIHEALTH-5
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Coordinator

MEDIZINISCHE HOCHSCHULE HANNOVER
Address
Carl-neuberg-str.1
Hannover
Germany

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Participants (27)

AMYNON BIOTECH GMBH
Austria
Address
Schneeburgasse, 76A
Innsbruck

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ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
Address
Administration Building - University Campus
Thessaloniki

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ARTTIC
France
Address
58A, Rue Du Dessous Des Berges
Paris

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AUSTRIAN ACADEMY OF SCIENCES - OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN
Austria
Address
Dr. Ignaz Seipel-platz 2
Vienna

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CANAG DIAGNOSTICS AB
Sweden
Address
Majnabbe Terminal Bldg
Göteborg

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DEUTSCHES KREBSFORSCHUNGSZENTRUM
Germany
Address
Im Neuenheimer Feld 280
Heidelberg

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EBERHARD-KARLS-UNIVERSITAET TUEBINGEN
Germany
Address
Wilhelmstr. 7
Tuebingen

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FACULTÉ UNIVERSITAIRE DES SCIENCES AGRONOMIQUES
Belgium
Address
Passage Des Déportés, 2
Gembloux

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FRIEDRICH-ALEXANDER UNIVERSITÄT ERLANGEN-NÜRNBERG
Germany
Address
Schlossplatz 4
Erlangen

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GENEDATA AG
Switzerland
Address
Maulbeerstrasse, 46
248 Basel

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HELSINGIN YLIOPISTO
Finland
Address
Yliopistonkatu 4
Helsingin Yliopisto, Helsinki

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IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Exhibition Road
London

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INSTITUT PASTEUR
France
Address
25-28, Rue Du Docteur Roux
Paris

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INSTITUTE OF MOLECULAR PATHOLOGY AND IMMUNOLOGY OF THE UNIVERSITY OF PORTO
Portugal
Address
Rua Roberto Frias S/n
Porto

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INTERNATIONAL AGENCY FOR RESEARCH ON CANCER
France
Address
150 Cours Albert Thomas
Lyon

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KAROLINSKA INSTITUTET
Sweden
Address
Nobels Väg 5
Stockholm

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KRAEFTENS BEKAEMPELSE - DANISH CANCER SOCIETY
Denmark
Address
Strandboulevarden 49
Copenhagen

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MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. - SOCIETY FOR THE ADVANCEMENT OF SCIENCE
Germany
Address
Hofgartenstrasse 8
Muenchen

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MOSAIQUES DIAGNOSTICS GMBH
Germany
Address
Mellendorfer Strasse 7
Hannover

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SMITTSKYDDSINSTITUTET - SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL
Sweden
Address
Nobels Väg 18
Solna

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THE UNIVERSITY OF BIRMINGHAM
United Kingdom
Address
Edgbaston
Birmingham

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UNIVERSITA' DEGLI STUDI DI PADOVA
Italy
Address
Via 8 Febbraio 2
Padova

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UNIVERSITY OF LEEDS
United Kingdom
Address
Woodhouse Lane
Leeds

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UNIVERSITÀ DEGLI STUDI DI MODENA E REGGIO EMILIA
Italy
Address
Via Università 4
Modena

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UNIVERSITÄTSKLINIKUM JENA
Germany
Address
Bachstrasse 18
Jena

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UNIVERSITÉ VICTOR SEGALEN BORDEAUX 2
France
Address
146 Rue Leo Saignat
Bordeaux Cedex

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VICHEM CHEMIE RESEARCH LTD.
Hungary
Address
Herman Ottó U. 15
Budapest

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