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The European Mouse Genome Mutagenesis Program

The European Mouse Genome Mutagenesis Program

Objective

The EUCOMM integrated project responds to the priority topic defined by Priority 1. Life Sciences and Biotechnology for Health, 'Genome-wide Mutagenesis in Mouse'. EUCOMM integrates European skills, efforts, resources, and infrastructure to produce, in a systematic high throughput way, mutations throughout the mouse genome. A collection of up to 20.000 mutated genes will be generated in mouse embryonic stem (ES) cells using conditional gene trapping and gene targeting approaches. This library will enable mouse mutants to be established worldwide in a standardized and cost-effective manner, making mouse mutants available to a much wider biomedical research community than has been possible previously. For a subset of genes relevant for human disease, mutant mice will be established, archived and analyzed. This will offer an opportunity to decipher molecular disease mechanisms and in some cases provide a foundation for the development of diagnostic, prognostic and therapeutic strategies. This project is built on exceptionally strong European expertise in mouse molecular genetics, genomics and bioinformatics and will enable automation of targeting vector production and professional dissemination of material. EUCOMM will foster integration with existing European consortia which address mouse gene expression analysis, mutant phenotyping, imaging and archiving. Progress of all of these projects will be enhanced by EUCOMM mouse mutants. All targeting vectors, mutant ES cells, mouse resources, and Standard Operating Procedures generated by EUCOMM will be displayed to the scientific community via the EUCOMM web linked database, other EU consortia databases and the Ensembl browser, and distributed professionally. Taken together, EUCOMM will make a major contribution to the analysis of gene function. Finally, EUCOMM resources represent major opportunities for exploitation by SMEs and the pharmaceutical industry.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

HELMHOLTZ ZENTRUM MÜNCHEN

Address

Ingolstaedter Landstrasse 1
Neuherberg

Germany

Administrative Contact

Wolfgang WURST (Professor)

Participants (10)

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GENOME RESEARCH LIMITED

United Kingdom

UNIVERSITY HOSPITAL OF THE JOHANN WOLFGANG GOETHE UNIVERSITY FRANKFURT

Germany

CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN

Germany

TECHNISCHE UNIVERSITAET DRESDEN

Germany

GENE BRIDGES GMBH

Germany

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE - GROUPEMENT D'INTERET ECONOMIQUE

France

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

MEDICAL RESEARCH COUNCIL

United Kingdom

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

RZPD - DEUTSCHES RESSOURCENZENTRUM FUR GENOMFORSCHUNG GMBH

Germany

Project information

Grant agreement ID: 18931

  • Start date

    1 January 2006

  • End date

    31 December 2011

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 17 510 637

  • EU contribution

    € 13 000 000

Coordinated by:

HELMHOLTZ ZENTRUM MÜNCHEN

Germany