Development and application of biomarkers of dietary exposure to genotoxic and immunotoxic chemicals and of biomarkers of early effects, using mother-child birth cohorts and biobanks

Objective

NewGeneris will test the hypothesis that maternal exposure to dietary compounds with carcinogenic and iimunotoxic properties results in in utero exposure and molecular events in the unborn child leading to increased risk of cancer and imnune disorders in later childhood. B??rmarkers of exposure, carcinogenic and iimunotoxic risks and of susceptibility will be developed and applied using higfr throughput techniques. Existing European mother-child birth cohorts will be used while new biobanks will be set up in different European regions to generate specific information, and to collect uitoilical cord blood sanples. Training and educational activities will be carried out. New3eneris will address the following objectives:
(1) Dietary exposure of pregnant wonnen to dietary carcinogens and iirmunotoxins will be assessed using available questionnaires fron existing mother/child birth cohorts.
(2)Epidemiological surveys of mother/child birth cohorts will be used to study associations between maternal dietary exposure, and childhood cancer risk factors and imnune disorders
(3) Paternal exposure to dietary toxins will be considered as an additional genetic risk.
(4) An in vitro model of transplacental perfusion will be used to better understand in utero exposure to selected toxins.
(5) In cord blood sanples from existing cohorts and newly initiated biobanks bianarkers will be used to assess fetal exposure to these compounds and compared with maternal exposure.
(6) In the sane sanples, genetic pathways indicative of risks of cancer and immune disorders in later childhood will be studied by analysis of lynphocytic gene expression and protecmics profiles.
(7) Liter-individual variability in responses will be evaluated by gene-typing of infants' ENA, and by phenotyping for ENA-repair activities.
(8) Overall public health implications as well as ethical issues, will be addressed.
(9) Results will be disseminated to EU food industry.

Field of science

• /medical and health sciences/health sciences/public and environmental health
• /engineering and technology/other engineering and technologies/food and beverages/food safety
• /medical and health sciences/clinical medicine/cancer
• /medical and health sciences/clinical medicine/embryology
• /social sciences/sociology/demography/fertility

Programme(s)

• FP6-FOOD - Food Quality and Safety: Thematic priority 5 under the Focusing and Integrating Community Research programme 2002-2006.

Topic(s)

• FOOD-2004-T5.4.8.2 - Developing biomarkers of exposure to chemicals and biomarkers of effects, using mother-child birth cohorts and biobanks

Call for proposal

FP6-2004-FOOD-3-A
See other projects for this call

Funding Scheme

IP - Integrated Project

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Coordinator

MAASTRICHT UNIVERSITY

Address

Minderbroedersberg 4-6
616 Maastricht
Netherlands

Participants (24)

NATIONAL HELLENIC RESEARCH FOUNDATION

Greece

Address

48, Vassileos Constantinou Avenue
Athens

FUNDACIO IMIM

Spain

Address

Passeig Maritim, 25
Barcelona

THE UNIVERSITY OF BRADFORD

United Kingdom

Address

Richmond Road
Bradford

UNIVERSITY OF COPENHAGEN

Denmark

Address

Norregade 10
2177 Copenhagen

UNIVERSITY OF LEICESTER

KAROLINSKA INSTITUTET

Sweden

Address

Nobels Väg 5, Solna
Stockholm

VRIJE UNIVERSITEIT BRUSSEL

Belgium

Address

Pleinlaan 2
Brussels

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

Address

Im Neuenheimer Feld 280
10 19 49 Heidelberg

UNIVERSITET I OSLO

Norway

Address

Problemveien 7
1072 Blindern Oslo

ISTITUTO NAZIONALEPER LA RICERCA SUL CANCRO

Italy

Address

Largo Rosanna Benzi, 10
Genova

UNIVERSITY OF LEEDS

United Kingdom

Address

Woodhouse Lane
616 Leeds

KATHOLIEKE UNIVERSITEIT LEUVEN

NORWEGIAN INSTITUTE OF PUBLIC HEALTH

Norway

Address

Geitmyrsveien 75
4404, Nydalen Oslo

STATENS SERUM INSTITUT

Denmark

Address

Artillerivej 5
Copenhagen S

UNIVERSITY OF CRETE

Greece

Address

Leof. Knossou
Heraklion

UNIVERSITY OF EASTERN FINLAND (ITÄ-SUOMEN YLIOPISTO)

Finland

Address

Savilahdentie 9
1627 Kuopio

STOCKHOLMS UNIVERSITET

Sweden

Address

Universitetsvaegen 10
Stockholm

INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH

Croatia

Address

Ksaverska C 2
Zagreb

UNIVERSITAT AUTONOMA DE BARCELONA

Spain

Address

Campus De Bellaterra
Cerdanyola Del Valles (Barcelona)

SLOVAK MEDICAL UNIVERSITY (BRATISLAVA)

Slovakia

Address

Limbova 12
Bratislava

BIODETECTION SYSTEMS BV

Netherlands

Address

Kruislaan 406
Amsterdam

IMSTAR S.A.

France

Address

Rue Notre Dame Des Champs 60
Paris

GENEDATA AG

Switzerland

Address

Maulbeerstrasse 46
Basel

NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH

Hungary

Address

Gyáli Út 2-6
Budapest