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Development and application of biomarkers of dietary exposure to genotoxic and immunotoxic chemicals and of biomarkers of early effects, using mother-child birth cohorts and biobanks

Objective

NewGeneris will test the hypothesis that maternal exposure to dietary compounds with carcinogenic and iimunotoxic properties results in in utero exposure and molecular events in the unborn child leading to increased risk of cancer and imnune disorders in later childhood. B??rmarkers of exposure, carcinogenic and iimunotoxic risks and of susceptibility will be developed and applied using higfr throughput techniques. Existing European mother-child birth cohorts will be used while new biobanks will be set up in different European regions to generate specific information, and to collect uitoilical cord blood sanples. Training and educational activities will be carried out. New3eneris will address the following objectives:
(1) Dietary exposure of pregnant wonnen to dietary carcinogens and iirmunotoxins will be assessed using available questionnaires fron existing mother/child birth cohorts.
(2)Epidemiological surveys of mother/child birth cohorts will be used to study associations between maternal dietary exposure, and childhood cancer risk factors and imnune disorders
(3) Paternal exposure to dietary toxins will be considered as an additional genetic risk.
(4) An in vitro model of transplacental perfusion will be used to better understand in utero exposure to selected toxins.
(5) In cord blood sanples from existing cohorts and newly initiated biobanks bianarkers will be used to assess fetal exposure to these compounds and compared with maternal exposure.
(6) In the sane sanples, genetic pathways indicative of risks of cancer and immune disorders in later childhood will be studied by analysis of lynphocytic gene expression and protecmics profiles.
(7) Liter-individual variability in responses will be evaluated by gene-typing of infants' ENA, and by phenotyping for ENA-repair activities.
(8) Overall public health implications as well as ethical issues, will be addressed.
(9) Results will be disseminated to EU food industry.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /engineering and technology/other engineering and technologies/food and beverages/food safety
  • /medical and health sciences/clinical medicine/cancer
  • /medical and health sciences/clinical medicine/embryology
  • /social sciences/sociology/demography/fertility

Call for proposal

FP6-2004-FOOD-3-A
See other projects for this call

Funding Scheme

IP - Integrated Project
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Coordinator

MAASTRICHT UNIVERSITY
Address
Minderbroedersberg 4-6
616 Maastricht
Netherlands

Participants (24)

NATIONAL HELLENIC RESEARCH FOUNDATION
Greece
Address
48, Vassileos Constantinou Avenue
Athens
FUNDACIO IMIM
Spain
Address
Passeig Maritim, 25
Barcelona
THE UNIVERSITY OF BRADFORD
United Kingdom
Address
Richmond Road
Bradford
UNIVERSITY OF COPENHAGEN
Denmark
Address
Norregade 10
2177 Copenhagen
UNIVERSITY OF LEICESTER
KAROLINSKA INSTITUTET
Sweden
Address
Nobels Väg 5, Solna
Stockholm
VRIJE UNIVERSITEIT BRUSSEL
Belgium
Address
Pleinlaan 2
Brussels
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
Address
Im Neuenheimer Feld 280
10 19 49 Heidelberg
UNIVERSITET I OSLO
Norway
Address
Problemveien 7
1072 Blindern Oslo
ISTITUTO NAZIONALEPER LA RICERCA SUL CANCRO
Italy
Address
Largo Rosanna Benzi, 10
Genova
UNIVERSITY OF LEEDS
United Kingdom
Address
Woodhouse Lane
616 Leeds
KATHOLIEKE UNIVERSITEIT LEUVEN
NORWEGIAN INSTITUTE OF PUBLIC HEALTH
Norway
Address
Geitmyrsveien 75
4404, Nydalen Oslo
STATENS SERUM INSTITUT
Denmark
Address
Artillerivej 5
Copenhagen S
UNIVERSITY OF CRETE
Greece
Address
Leof. Knossou
Heraklion
UNIVERSITY OF EASTERN FINLAND (ITÄ-SUOMEN YLIOPISTO)
Finland
Address
Savilahdentie 9
1627 Kuopio
STOCKHOLMS UNIVERSITET
Sweden
Address
Universitetsvaegen 10
Stockholm
INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH
Croatia
Address
Ksaverska C 2
Zagreb
UNIVERSITAT AUTONOMA DE BARCELONA
Spain
Address
Campus De Bellaterra
Cerdanyola Del Valles (Barcelona)
SLOVAK MEDICAL UNIVERSITY (BRATISLAVA)
Slovakia
Address
Limbova 12
Bratislava
BIODETECTION SYSTEMS BV
Netherlands
Address
Kruislaan 406
Amsterdam
IMSTAR S.A.
France
Address
Rue Notre Dame Des Champs 60
Paris
GENEDATA AG
Switzerland
Address
Maulbeerstrasse 46
Basel
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH
Hungary
Address
Gyáli Út 2-6
Budapest