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Development and application of biomarkers of dietary exposure to genotoxic and immunotoxic chemicals and of biomarkers of early effects, using mother-child birth cohorts and biobanks

Objective

NewGeneris will test the hypothesis that maternal exposure to dietary compounds with carcinogenic and iimunotoxic properties results in in utero exposure and molecular events in the unborn child leading to increased risk of cancer and imnune disorders in later childhood. B??rmarkers of exposure, carcinogenic and iimunotoxic risks and of susceptibility will be developed and applied using higfr throughput techniques. Existing European mother-child birth cohorts will be used while new biobanks will be set up in different European regions to generate specific information, and to collect uitoilical cord blood sanples. Training and educational activities will be carried out. New3eneris will address the following objectives:
(1) Dietary exposure of pregnant wonnen to dietary carcinogens and iirmunotoxins will be assessed using available questionnaires fron existing mother/child birth cohorts.
(2)Epidemiological surveys of mother/child birth cohorts will be used to study associations between maternal dietary exposure, and childhood cancer risk factors and imnune disorders
(3) Paternal exposure to dietary toxins will be considered as an additional genetic risk.
(4) An in vitro model of transplacental perfusion will be used to better understand in utero exposure to selected toxins.
(5) In cord blood sanples from existing cohorts and newly initiated biobanks bianarkers will be used to assess fetal exposure to these compounds and compared with maternal exposure.
(6) In the sane sanples, genetic pathways indicative of risks of cancer and immune disorders in later childhood will be studied by analysis of lynphocytic gene expression and protecmics profiles.
(7) Liter-individual variability in responses will be evaluated by gene-typing of infants' ENA, and by phenotyping for ENA-repair activities.
(8) Overall public health implications as well as ethical issues, will be addressed.
(9) Results will be disseminated to EU food industry.

Coordinator

MAASTRICHT UNIVERSITY

Address

Minderbroedersberg 4-6
616 Maastricht

Netherlands

Administrative Contact

Jos KLEINJANS (Professor)

Participants (24)

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NATIONAL HELLENIC RESEARCH FOUNDATION

Greece

FUNDACIO IMIM

Spain

THE UNIVERSITY OF BRADFORD

United Kingdom

UNIVERSITY OF COPENHAGEN

Denmark

UNIVERSITY OF LEICESTER

KAROLINSKA INSTITUTET

Sweden

VRIJE UNIVERSITEIT BRUSSEL

Belgium

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

UNIVERSITET I OSLO

Norway

ISTITUTO NAZIONALEPER LA RICERCA SUL CANCRO

Italy

UNIVERSITY OF LEEDS

United Kingdom

KATHOLIEKE UNIVERSITEIT LEUVEN

NORWEGIAN INSTITUTE OF PUBLIC HEALTH

Norway

STATENS SERUM INSTITUT

Denmark

UNIVERSITY OF CRETE

Greece

UNIVERSITY OF EASTERN FINLAND (ITÄ-SUOMEN YLIOPISTO)

Finland

STOCKHOLMS UNIVERSITET

Sweden

INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH

Croatia

UNIVERSITAT AUTONOMA DE BARCELONA

Spain

SLOVAK MEDICAL UNIVERSITY (BRATISLAVA)

Slovakia

BIODETECTION SYSTEMS BV

Netherlands

IMSTAR S.A.

France

GENEDATA AG

Switzerland

NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH

Hungary

Project information

Grant agreement ID: 16320

  • Start date

    1 February 2006

  • End date

    31 July 2011

Funded under:

FP6-FOOD

  • Overall budget:

    € 15 661 101

  • EU contribution

    € 13 594 976

Coordinated by:

MAASTRICHT UNIVERSITY

Netherlands