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European Rat Tools for Functional Genomics

European Rat Tools for Functional Genomics

Objective

Determining the molecular basis of natural phenotypic variation, including inter-individual susceptibility to common diseases, is a central challenge of post-genome genetics. The rat is a leading model species for research in physiology, pharmacology and toxicology, and for the study of a wide range of common, genetically complex human diseases. Decades of exquisite phenotyping and detailed analyses in rat experimental crosses have led to localization of hundreds of quantitative trait loci (QTLs) contai ning genes that confer susceptibility to complex disease phenotypes. However in common with studies in other organisms, few genes underlying these genetically complex traits have as yet been identified. The availability of the rat genome sequence and g enome-scale technologies, along with the ability to clone fertile adult rats, has substantially advanced the potential for functional genomics research in the rat model. The European Rat Tools for Functional Genomics (EURATools) consortium draws together leading European researchers in rat genetics, pharmacology, toxicology, disease pathophysiology, and genome biology and informatics. The central aim of this project is the development of integrated genome tools that will generate knowledge which can be translated into improvements in healthcare for highly prevalent diseases in the European Union. The EURATools aims will be achieved by integrating high-throughput sequencing and genotyping with informatics; by intensive analysis of phenotypes, gene seq uence and gene expression in congenic strains to identify genes and regulatory pathways for a wide range of rat disease phenotypes; and by establishment of optimised protocols for rat gene targeting. These new resources will significantly improve our und erstanding of complex genetic traits, and will enhance prospects for drug development and strategies for preventing and treating some of the commonest diseases in western societies.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

MEDICAL RESEARCH COUNCIL

Address

20 Park Cresent
N/A London

United Kingdom

Administrative Contact

Timothy J. AITMAN (Professor)

Participants (16)

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MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

Germany

THE UNIVERSITY OF EDINBURGH

United Kingdom

INSTITUTE OF PHYSIOLOGY, CZECH ACADEMY OF SCIENCES

Czechia

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

UNIVERSITY OF GLASGOW

United Kingdom

LUNDS UNIVERSITET

Sweden

UNIVERSITE LIBRE DE BRUXELLES

Belgium

COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

UNIVERSITAT AUTÒNOMA DE BARCELONA

Spain

KAROLINSKA INSTITUTET

Sweden

INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES

China

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

GENOWAY SA

France

CXR BIOSCIENCES LIMITED

United Kingdom

MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

Germany

Project information

Grant agreement ID: 19015

  • Start date

    1 March 2006

  • End date

    31 August 2010

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 14 491 236

  • EU contribution

    € 11 000 000

Coordinated by:

MEDICAL RESEARCH COUNCIL

United Kingdom