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Role of p63 and related pathways in epithelial stem cell proliferation and differentiation and in rare EEC-related syndromes.

Objective

The focus of 'EPISTEM' is to generate new knowledge and translate it into applications that enhance human health. To this end both fundamental and applied research will be involved. 'EPISTEM' integrates multidisciplinary and coordinated efforts to understand the molecular basis of factors involved in epidermal stem cell generation, maintenance and differentiation and skin disease. Moreover, the core molecule that will be studied in this IP is p63 (and related pathways), a molecule genetically proven to be involved in the development of rare skin diseases such as EEC syndrome, Hay-Wells (AEC) syndrome, Limb-mammary syndrome, ADULT syndrome, Rapp-Hodgkin syndrome and non-syndromic split hand-split foot malformation. Collectively, the prevalence of ectodermal dysplasia syndromes (EDS) is estimated at 7 cases in 10,000 births. Currently there is no cure for these patients. By creating the 'EPISTEM' consortium we want to address from different angles (genetics, gene profiling, molecular and cellular biology, structural biology, drug design, bioinformatics), the molecular pathways involved in epidermal dysplasia syndromes making use of different technologies (mutation analysis, micro-array, ChiP, transgenes, proteomics, in vitro skin cultures, crystallography, etc). Our consortium brings together leading European clinicians, geneticists, molecular and cellular biologists, structural biologists, a drug designer and bioinformatics specialist in the field of p63 (and related molecules) research. Therefore, this research fits in the centre of the specific topic "Exploring the potential of stem cells and/or primary cells for the understanding of monogenic rare diseases and the development of new drugs for their treatments".

Call for proposal

FP6-2004-LIFESCIHEALTH-5
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Funding Scheme

IP - Integrated Project

Coordinator

FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW
Address
Rijvisschestraat 120
Gent-zwijnaarde
Belgium

Participants (12)

RADBOUD UNIVERSITEIT NIJMEGEN
Netherlands
Address
Geert Grooteplein Zuid 10
Nijmegen
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
Address
Via Orazio Raimondo 18
Rome
UNIVERSITY OF LAUSANNE
Switzerland
Address
Bâtiment Du Rectorat Et De L'administration (Bra)
Lausanne
KING'S COLLEGE LONDON
United Kingdom
Address
Strand
London
KAROLINSKA INSTITUTET
Sweden
Address
Nobels Väg 5
Stockholm
INSTITUTO ONCOLOGICO DEL MEDITERRANEO SPA
Italy
Address
Via Penninazoo Nr 7
Viagrande (Ct)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac
Paris
GENESPIN SRL
Italy
Address
Via Celoria 26
Milano
CHIANG MAI UNIVERSITY
Thailand
Address
239, Huay Kaew Road
Chiang Mai
SHANGHAI JIAOTONG UNIVERSITY, SHANGHAI, P.R. CHINA
China
Address
1954, Huashan Road
Shanghai
J. W. GOETHE-UNIVERSITÄT FRANKFURT AM MAIN
Germany
Address
Senckenberganlage 31
Frankfurt / Main
UNIVERSITÀ DEGLI STUDI DI MILANO
Italy
Address
Via Festa Del Perdono 7
Milano