Molecular and genetic research is now providing us with the opportunity to quantify the risks of radiation exposure at the individual level. The retrospective analysis of earlier epidemiological and animal studies will be an important resource for modelling and evaluating such new risk parameters. With great foresight the EU and EULEP have created a database collecting and collating data from almost all of the available animal radiation biology studies carried out in Europe, the US and Japan between 1960 and 1998, plus those of two human cohort studies. This database is called the European Radiobiology Archives (ERA). Funding for the long-term maintenance of ERA is assured from other sources. This proposal for specific support is designed only to maximise the exploitation of the resource, making ERA accessible to the greatest number of end-users. This will be done by making the archive accessible on line (e.ERA), while assuring controlled user access. The dissemination of e.ERA will then be promoted by presentations at major scientific conferences and by two training workshops. In addition, e.ERA will be made compatible to and interoperable with other relevant radiobiological databases, namely JRA, NRA, PATHBASE, and other mouse phenotype projects. One major aim is to establish recoding of the pathology data in ERA to conform with accepted ontology standards (MPATH) for the mouse. Finally the possibility of expanding the database to include data from other projects and to establish a tissue data bank will be examined; the actual modification of the database to do this would not however form part of this proposal. We will deliver a unique on-line repository of archival data, the project will put into effect an easy to use database of invaluable data for further exploitation by the scientific community. The work will be finished within the project's duration, and the contractors will then undertake to sustain this research tool from their own Institutional resources.
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