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Targeting replication and integration of HIV

Objective

Anti-HIV drugs, used at present in the clinic, target the viral reverse transcriptase (RT) or protease (PR). Combination therapies are the current standard of care. However, as a result of insufficient drug plasma levels or of insufficient inhibitory power of the chosen drug combination, drug resistant strains emerge, resulting in therapeutic failure. Consequently, there is a continuing need for new anti-HIV drugs to be used in combination with the current drugs, which should represent novel chemical entities targeting known targets (viral entry,reverse transcription), or should act on new viral targets of the HIV replication cycle (e.g. nucleocapsid, integrase) or interfere with cellular co-factors required for HIV replication.
The general objective of TRIoH is to integrate the different research efforts from different European partners on novel anti-HIV molecules targeting viral replication and integration. Our central scientific paradigm is the molecular continuum between the different HIV early replication steps starting with viral entry and leading to integration. We will use multidisciplinary proteomics approaches to study the basic science of HIV replication andintegration. There is special focus on the identification of new, cellular host factors. Our research will foster a technological platform of academic and industrial partners and result in more efficient development of new drugs and therapies by providing new assays and new targets. Basic science, biotechnology and provocative chemistry will guide the development of new HIV therapeutics. Identified lead compounds of participating partners will be developed preclinically, ready for Phase 1 clinical trials. Different Biotech SMEs are actively involved in the development and valorisation program. Our project will include all aspects of present day drug development starting with chemical synthesis up to preclinical evaluation in animal models.

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
Oude Markt 13
Leuven
Belgium

Participants (24)

FUNDACIO IRSICAIXA
Spain
Address
C. Canyet S/n
Badalona
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
101 Rue De Tolbiac
Paris
UNIVERSITAT DE BARCELONA
Spain
Address
Vicerectorat De Politica Cientifica (Oper), Gran Via 585
Barcelona
UNIVERSITY OF MESSINA - DIPARTIMENTO FARMACO-CHIMICO
Italy
Address
Piazza Pugliatti
Messina
GEORG-SPEYER-HAUS
Germany
Address
Paul-ehrlich-str. 42-44
Frankfurt Am Main
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel Ange 3
Paris
JOHANN WOLFGANG GOETHE-UNIVERSITAT FRANKFURT
Germany
Address
Senckenberganlage 31
Frankfurt Am Main
BELOZERSKY INSTITUTE OF PHYSICO-CHEMICAL BIOLOGY LOMONOSOV MOSCOW STATE UNIVERSITY
Russia
Address
Leninskie Gory, Msu
Moscow
HERIOT-WATT UNIVERSITY
United Kingdom
Address
Riccarton
Edinburgh
BIJVOET CENTER FOR BIOMOLECULAR RESEARCH, FACULTY OF CHEMISTRY, UTRECHT UNIVERSITY
Netherlands
Address
Padualaan 8
Utrecht
UNIVERSITY OF HEIDELBERG, GERMANY
Germany
Address
Vostr. 2
Heidelberg
UNIVERSITY OF SZEGED
Hungary
Address
Dugonics Ter 13
Szeged
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Address
Piazzale Aldo Moro 7
Rome
UNIVERSITY OF SEVILLE
Spain
Address
San Fernando, 4
Seville
INSTITUTE OF NUCLEAR SCIENCES VINCA
Address
Mihajla Petrovica 12-14
522 Belgrade
MEDIVIR AB
Sweden
Address
Lunastigen 7
Huddinge
HYBRIGENICS SA
France
Address
3-5 Impasse Reille
Paris
PEPSCAN SYSTEMS B.V.
Netherlands
Address
Edelhertweg 15
2098 Lelystad
ECOLE NORMALE SUPERIEURE DE CACHAN
France
Address
Avenue Du President Wilson 61
Cachan
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Address

Lausanne
UNIVERSIDAD "MIGUEL HERNANDEZ"
Spain
Address
Avda. Del Ferrocarril, S/n - Campus De Elche
Elche-alicante
UNIVERSITA DEGLI STUDI DI SIENA
Italy
Address
Banchi Di Sotto, 55
Siena
UNIVERSITATSKLINIKUM SCHLESWIG-HOLSTEIN, CAMPUS LUBECK, INSTITUT FUR MOLEKULARE MEDIZIN
Germany
Address
Ratzeburger Allee 160
Lubeck
UNIVERSITE LOUIS PASTEUR
France
Address
4 Rue Blaise Pascal
Strasbourg