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European Microbicides Project

Objective

This proposal aims to develop new topical microbicides that block entry of HIV at mucosal sites with the aim of establishing a pipeline of candidate microbicides while taking selected microbicides through Phase I clinical trial. The proposed programme will bring together leading European experts in this field to work on an integrated programme of research. Members of the consortium have extensive expertise in analyses of molecular structure,molecular interactions, investigation of mechanisms of HIV infection, testing efficacy in animal models, development of methods for large-scale production of microbicides, mucosal delivery and the conduct of clinical trials particularly in developing countries. The proposal builds on this strength and describes novel approaches to develop new microbicides. Novel molecules and combinatorial peptide, polypeptide and oligosaccharide libraries will be screend for inhibitors that are specifically targeted to viral envelope proteins or host receptors.
Microbicidal efficacy of inhibitors will be rigorously tested in vitro and the most promising will be formulated and tested in animal models. The developmental process for candidate agents will be target-driven according to an established preclinical selection algorithm designed to fast track the most promising candidates and/or combination. This process will not be carried out in isolation from the rest of the International field, indeedparticular emphasis will be placed on development of compounds demonstrating synergistic activity with first generation compounds further ahead in the developmental process. The programme will operate like a virtual company allowing strategic developmental and budgetary decisions to be continuously reviewed. As well as identifying novel candidate microbicides, the programme should provide a rational basis for the design of 2nd or3rd generation microbicides.

Call for proposal

FP6-2002-LIFESCIHEALTH
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

KING'S COLLEGE, LONDON'
Address
Strand
London
United Kingdom

Participants (30)

ST. GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
Address
Cranmer Terrace, Tooting
London
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
Oude Markt 13
Leuven
INSERM ADR PARIS
France
Address
2 Ter Rue D'alesia
Paris
CARBOHYDRATE SYNTHESIS LIMITED
United Kingdom
Address
Building 15, North Culham Estate, Culham Science Centre
Abingdon
UNIVERSITA DEGLI STUDI DI MILANO
Italy
Address
Via Festa Del Perdono, 7
Milano
ABLYNX N.V.
Belgium
Address
Technologiepark 4
Zwynaarde, Ghent
ISTITUTO SUPERIORE DI SANITÀ
Italy
Address
Viale Regina Elena 299
Rome
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
COMMISSARIAT À L'ENERGIE ATOMIQUE'
France
Address
31-33 Rue De La Fédération
Paris
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
Address
Via Olgettina, 60
Milano
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS
Spain
Address
Serrano 117
Madrid
PEPSCAN SYSTEMS BV
Netherlands
Address
Edelhertweg 15
2098 Lelystad
GLYCORES 2000 SRL
Italy
Address
Via Macmahon 43
Milano
UNIVERSITÀ DEGLI STUDI DI SIENA
Italy
Address
Banchi Di Sotto, 55
Siena
TECHNISCHE UNIVERSITÄT MÜNCHEN
Germany
Address
Arcisstr. 21
München
UNIVERSITY OF STELLENBOSCH
South Africa
Address

Matieland Stellenbosch
PRINCE LEOPOLD INSTITUTE OF TROPICAL MEDICINE, ANTWERP
Belgium
Address
Nationalestraat 155
Anwerpen
CENTRE INTERNATIONAL DE RECHERCHES MÉDICALES DE FRANCEVILLE
Gabon
Address

BP 769 Franceville
BIOZENTRUM DER UNIVERSITÄT BASEL
Switzerland
Address
Klingelbergstrasse 70
Basel
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London
TIBOTEC PHARMACEUTICALS LTD
Ireland
Address
Unit 4 Block 4B Blanchardstown Corporate Park
Dublin
THE UNIVERSITY OF READING
United Kingdom
Address
Whiteknights
Reading
UNIVERSITY OF YORK
United Kingdom
Address
Heslington
York
COUNCIL FOR SCIENTIFIC & INDUSTRIAL RESEARCH
South Africa
Address
Meiring Naudé Street
395 Pretoria
UNIVERSITY UTRECHT, DEPARTMENT OF BIOLOGY
Netherlands
Address
Sorbonnelaan 16
80084 Utrecht
POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH
Austria
Address
Nussdorfer Laende 11
Vienna
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES - CIC BIOMAGUNE
Spain
Address
Paseo Miramon 182. Edificio Empresarial C
San Sebastian (Guipuzcoa)
PEPSCAN THERAPEUTICS BV
Netherlands
Address
Zuidesluisweg
2098 Lelysted
QUEEN'S UNIVERSITY BELFAST'
United Kingdom
Address
University Road
Belfast