This proposal aims to develop new topical microbicides that block entry of HIV at mucosal sites with the aim of establishing a pipeline of candidate microbicides while taking selected microbicides through Phase I clinical trial. The proposed programme will bring together leading European experts in this field to work on an integrated programme of research. Members of the consortium have extensive expertise in analyses of molecular structure,molecular interactions, investigation of mechanisms of HIV infection, testing efficacy in animal models, development of methods for large-scale production of microbicides, mucosal delivery and the conduct of clinical trials particularly in developing countries. The proposal builds on this strength and describes novel approaches to develop new microbicides. Novel molecules and combinatorial peptide, polypeptide and oligosaccharide libraries will be screend for inhibitors that are specifically targeted to viral envelope proteins or host receptors.
Microbicidal efficacy of inhibitors will be rigorously tested in vitro and the most promising will be formulated and tested in animal models. The developmental process for candidate agents will be target-driven according to an established preclinical selection algorithm designed to fast track the most promising candidates and/or combination. This process will not be carried out in isolation from the rest of the International field, indeedparticular emphasis will be placed on development of compounds demonstrating synergistic activity with first generation compounds further ahead in the developmental process. The programme will operate like a virtual company allowing strategic developmental and budgetary decisions to be continuously reviewed. As well as identifying novel candidate microbicides, the programme should provide a rational basis for the design of 2nd or3rd generation microbicides.
Call for proposal
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Funding SchemeIP - Integrated Project
BP 769 Franceville