Obiettivo Vast amounts of money are being spent on drugs acting on membrane proteins without knowledge of the molecular details of their mode of action. Even though the genes of membrane proteins are now accessible, solving their structure remains time-consuming an d often unsuccessful. Given their physiological and biomédical importance, this constitutes a major problem in basic life sciences as well as public health care. Tools have been developed to overexpress, solubilize, stabilize, purify and crystallize membra ne proteins, and they are currently being used in large-scale initiatives for structure determination. Unfortunately, most membrane proteins resist one or more of these steps. The objective of IMPS is to develop imaginative, broad-range tools for membrane structural proteomics. The project brings together experts in chemistry, biochemistry, molecular genetics and crystallography and aims at developing original, innovative tools to attack each of these stumbling blocks. A strong core of crystallographers wit h demonstrated expertise in membrane protein structure determination will apply these novel techniques to a representative test set of membrane proteins. The approaches to be developed include original overexpression systems (insect photoreceptor cells and the chloroplast), unconventional surfactants (amphipathic polymers, fluorinated surfactants, novel detergents and additives) and unconventional crystallization systems (lipid cubic phase crystallization, other non-detergent environments, molecular scaffol ding, bicelles). These novel methodologies will be made available to the community through a distributed technological platform including workshops, hands-on training, and dissemination of the new molecules, whose large-scale synthesis and distribution wil l be carried out by a participant SME. The circulation of scientists between IMPS laboratories will guarantee the rapid spread of the new know-how. Campo scientifico natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesmolecular biologymolecular geneticsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesearth and related environmental sciencesgeologymineralogycrystallographynatural sciencesbiological sciencesbiochemistrybiomoleculeslipids Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Invito a presentare proposte FP6-2003-LIFESCIHEALTH-I Vedi altri progetti per questo bando Meccanismo di finanziamento STIP - Specific Targeted Innovation Project Coordinatore CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Contributo UE Nessun dato Indirizzo 3, rue Michel-Ange PARIS Francia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto MEDICAL RESEARCH COUNCIL Regno Unito Contributo UE Nessun dato Indirizzo 20 Park Crescent LONDON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG Germania Contributo UE Nessun dato Indirizzo Seminarstr. 2 HEIDELBERG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato TARGETING SYSTEM PHARMA Francia Contributo UE Nessun dato Indirizzo 830, chemin de Vergon EGUILLES Mostra sulla mappa Costo totale Nessun dato UNIVERSITAET DES SAARLANDES Germania Contributo UE Nessun dato Indirizzo To be completed. SAARBRUECKEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITAT KONSTANZ Germania Contributo UE Nessun dato Indirizzo Universitätsstr. 10 KONSTANZ Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITÉ D'AVIGNON ET DES PAYS DE VAUCLUSE Francia Contributo UE Nessun dato Indirizzo 74, rue Louis Pasteur AVIGNON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato