Skip to main content

Paraneoplastic Neurological Syndromes (PNS) strengthening the European network

Objective

Paraneoplastic neurological syndromes (PNS) are severe disorders of the nervous system that arise as remote effects of neoplasia. Diagnosis of PNS is currently aided by detection, in patients' serum and cerebrospinal fluid, of specific autoantibodies that recognize antigens shared by the tumour and nervous system cells. In most cases, correct diagnosis of PNS permits early detection of the tumour, before it can metastasize. The rarity of PNS prompt the need for multicentric studies to collect sufficient numbers of patients on which to base specific studies. With the support of an EC grant (QLG1-CT-2002-01756), a Network of reference centres located in over 10 European nations was established for these pathologies (see www.pnseuronet.org). During the first 2 years of the scheduled 3 years' activity, a DATABASE has been developed and validated for the standardized collection of information on PNS patients dating from 2000, and a central bank set up to store biological material.
This Network has defined and published guidelines for the first time on PNS diagnosis, which will facilitate clinical diagnosis of the diseases and the collection of uniform groups of patients for specific studies. Over 500 cases have now been collected in the database which, considering the rarity of the diseases, is a very significant number, unmatched in the international literature. The aim of the project is to a) be able to continue, for 3 more years, to input patients in the database, making the necessary quality controls on incoming data, and to maintain centralized storage of biological material; b) diffuse information yielded by the database; identify and design specific studies on uniform groups of these diseases; and c) clinically characterize new PNS pathologies emerging from analysis of database information. No other international group is able to gather such an extensive case series. By continuing this cooperation, the EU would become world leader in PNS research.

Call for proposal

FP6-2004-LIFESCIHEALTH-5
See other projects for this call

Funding Scheme

SSA - Specific Support Action

Coordinator

REGIONE VENETO-AZIENDA U.L.S.S. N. 9 DI TREVISO
Address
Borgo Cavalli N 42
Treviso
Italy

Participants (21)

UNIVERSITA' CATTOLICA DEL SACRO CUORE
Italy
Address
Largo Agostino Gemelli,1
Milan
UNIVERSITÀ DEGLI STUDI DI TORINO
Italy
Address
Via Cherasco 15
Torino
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101 Rue De Tolbiac
Paris
UNIVERSITY HOSPITAL OF THE UNIVERSITY OF COLOGNE
Germany
Address
Kerpener Str. 62
Cologne - Köln
INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER
Spain
Address
C/villarroel 170
Barcelona
FAKULTNI NEMOCNICE BRNO
Czechia
Address
Jihlavska 340/20
Brno
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
Address
Via Olgettina 60
Milan
ERASMUS UNIVERSITY MEDICAL CENTER
Netherlands
Address
Dr Molewaterplein 40
Rotterdam
LEIDEN UNIVERSITY MEDICAL CENTER
Netherlands
Address
Albinusdreef 2
9600 Leiden
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
UNIVERSITÉ JEAN-MONNET SAINT-ETIENNE
France
Address
Rue Francis Baulier, 34
Saint-etienne
INSTITUTE OF NEUROLOGY, UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Queen Square
London
LUDWIG BOLTZMANN INSTITUTE FOR NEUROONCOLOGY KAISER-FRANZ-JOSEF SPITAL OF THE CITY OF VIENNA
Austria
Address
Kundratstr. 3
Vienna
DEPARTMENT OF CLINICAL MEDICINE, SECTION FOR NEUROLOGY, UNIVERSITY OF BERGEN, NORWAY
Norway
Address
Haukeland University Hospital
Bergen
INSTITUTE OF CLINICAL NEUROPHYSIOLOGY, CLINICAL CENTER
Slovenia
Address
Zaloska 7
Ljubljana
UNIVERSITY OF LIVERPOOL
United Kingdom
Address
Senate House, Abercromby Square
Liverpool
AZIENDA OSPEDALIERA "M.MELLINI"
Italy
Address
V. Le Mazzini, 4
Chiari (Brescia)
MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH
Italy
Address
Via Eritrea, 62
Milano
UNIVERSITY OF MESSINA, MESSINA, ITALY
Italy
Address
Azienda Ospedaliera Universitaria Policlinico Di Messina, Via Consolare Valeria 1
Messina
JUSTUS-LIEBIG-UNIVERSITY GIESSEN
Germany
Address
Ludwigstrasse 23
Giessen
UNIVERSITATSKLINIKUM FREIBURG FUR DIE MEDIZINISCHE FAKULTAT DER ALBERT-LUDWIGS-UNIVERSITAT
Germany
Address
Breisacherstrasse 64
79095 Freiburg