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European alternative splicing network of excellence

Objective

Posttranscriptional events must play a more central role in generating the highly complex proteomes of metazoa than previously believed. This is shown by the large discrepancy between the number of coding sequences of metazoan genomes and the known diversi ty of gene products that they generate. Indeed, alternative pathways for processing the primary transcript of a gene can theoretically generate more transcripts and, ultimately, more protein variants (i.e. isoforms) than the number of classically defined genes in an entire organism. Thus, the process of alternative splicing can greatly expand the information content of genomes. Alternative splicing is an essential component of gene regulation, affecting every aspect of eucaryotic biology, and understanding the mechanisms that lead to alternatively spliced transcripts is essential for the functional interpretation of genomic sequences. In addition, a large number of genetic diseases are caused by defects in the proper processing of primary transcripts, and a lterations in alternative splicing are the basis for multiple human pathologies including cancer, viral infection and inflammatory responses. Despite its prevalence and significance, the molecular mechanisms that regulate alternative splicing are poorly un derstood. The EURASNET consortium employs a wide range of complementary approaches as computational, biochemical, proteomic, genomic, cell and organismal biology to study post-transcriptional gene regulation and its role in disease. The primary purpose of this network will be to develop an integrated approach for the study of alternative splicing that will 1 ) provide durable structures that change the way research in this field is carried out in Europe, 2) establish an innovative and multidisciplinary prog ramme of joint research activities, 3)spread excellence within Europe by establishing a career platform for young investigators, and 4) disseminate knowledge to the wider research and medical

Call for proposal

FP6-2004-LIFESCIHEALTH-5
See other projects for this call

Funding Scheme

NoE - Network of Excellence

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
Address
Hofgartenstrasse 8
Muenchen
Germany

Participants (31)

CENTRE DE REGULACIÓ GENÒMICA
Spain
Address
Passeig Maritim, 37-49
Barcelona
FRIEDRICH-ALEXANDER-UNIVERSITY-ERLANGEN-NURENBERG
Germany
Address
Schlossplatz 4
Erlangen
UPPSALA UNIVERSITY
Sweden
Address
Sankt Olofsgatan 10B
256 Uppsala
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
102209 Heidelberg
TEL AVIV UNIVERSITY
Israel
Address
Ramat Aviv
39040 Tel Aviv
INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY
Italy
Address
Padriciano 99
Trieste
MEDICAL UNIVERSITY VIENNA,
Austria
Address
Spitalgasse 23
Vienna
THE UNIVERSITY OF EDINBURGH
United Kingdom
Address
Old College, South Bridge
Edinburgh
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
Address
Piazzale Aldo Moro 7
Roma
JUSTUS-LIEBIG-UNIVERSITÄT GIESSEN
Germany
Address
Ludwigstr. 23
Giessen
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel Ange N° 3
Paris
UNIVERSITÄT BERN
Switzerland
Address
Hochschulstrasse 4
Bern
SCOTTISH CROP RESEARCH INSTITUTE
United Kingdom
Address
Invergowrie
Dundee
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20 Park Crescent
London
INSTITUTO DE MEDICINA MOLECULAR
Portugal
Address
Avenida Prof. Egas Moniz
Lisboa
UNIVERSITY OF LEICESTER
United Kingdom
Address
University Road
Leicester
ADAM MICKIEWICZ UNIVERSITY IN POZNAN
Poland
Address
Wieniawskiego 1
Poznan
UNIVERSITY OF AARHUS
Denmark
Address
Nordre Ringgade 1
Aarhus C
UNVERSIDAD DE BUENOS AIRES
Argentina
Address
Viamonte 430/444
Buenos Aires
UNIVERSITÉ DE GENÈVE
Switzerland
Address
24, Rue Du General Dufour
Geneva 4
UNIVERSITY OF DUNDEE
United Kingdom
Address
Nethergate
Dundee
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
The Old Schools, Trinity Lane
Cambridge
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
Address
The Authority For Research And Development, Edmond J. Safra Campus, Givat Ram
Jerusalem
CENTRE EUROPÉEN DE RECHERCHE EN BIOLOGIE ET MÉDECINE - GROUPEMENT D'INTÉRÊT ECONOMIQUE
France
Address
1 Rue Laurent Fries
10142 Illkirch
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101, Rue De Tolbiac
Paris
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
Address
Via Olgettina 60
Milano
SWISS INSTITUTE OF BIOINFORMATICS
Switzerland
Address
1 Rue Michel-servet
Geneva 4
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
Address
Raemistrasse 101
Zuerich
INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY
Poland
Address
Ksiecia Trojdena 4
Warsaw
UNIVERSITAT POMPEU FABRA
Spain
Address
Placa De La Merce, 10
Barcelona
UNIVERSITY OF SOUTHAMPTON
United Kingdom
Address
Highfield
Southampton So17 1Bj