CORDIS
EU research results

CORDIS

English EN

European alternative splicing network of excellence

Objective

Posttranscriptional events must play a more central role in generating the highly complex proteomes of metazoa than previously believed. This is shown by the large discrepancy between the number of coding sequences of metazoan genomes and the known diversi ty of gene products that they generate. Indeed, alternative pathways for processing the primary transcript of a gene can theoretically generate more transcripts and, ultimately, more protein variants (i.e., isoforms) than the number of classically defined genes in an entire organism. Thus, the process of alternative splicing can greatly expand the information content of genomes. Alternative splicing is an essential component of gene regulation, affecting every aspect of eucaryotic biology, and understanding the mechanisms that lead to alternatively spliced transcripts is essential for the functional interpretation of genomic sequences. In addition, a large number of genetic diseases are caused by defects in the proper processing of primary transcripts, and a lterations in alternative splicing are the basis for multiple human pathologies including cancer, viral infection and inflammatory responses. Despite its prevalence and significance, the molecular mechanisms that regulate alternative splicing are poorly un derstood. The EURASNET consortium employs a wide range of complementary approaches as computational, biochemical, proteomic, genomic, cell and organismal biology to study post-transcriptional gene regulation and its role in disease. The primary purpose of this network will be to develop an integrated approach for the study of alternative splicing that will 1 ) provide durable structures that change the way research in this field is carried out in Europe, 2) establish an innovative and multidisciplinary prog ramme of joint research activities, 3)spread excellence within Europe by establishing a career platform for young investigators, and 4) disseminate knowledge to the wider research and medical

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

Address

Hofgartenstrasse 8
Muenchen

Germany

Administrative Contact

Reinhard LÜHRMANN (Professor)

Participants (31)

Sort alphabetically

Expand all

CENTRE DE REGULACIÓ GENÒMICA

Spain

FRIEDRICH-ALEXANDER-UNIVERSITY-ERLANGEN-NURENBERG

Germany

UPPSALA UNIVERSITY

Sweden

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

TEL AVIV UNIVERSITY

Israel

INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY

Italy

MEDICAL UNIVERSITY VIENNA,

Austria

THE UNIVERSITY OF EDINBURGH

United Kingdom

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

JUSTUS-LIEBIG-UNIVERSITÄT GIESSEN

Germany

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

UNIVERSITÄT BERN

Switzerland

SCOTTISH CROP RESEARCH INSTITUTE

United Kingdom

MEDICAL RESEARCH COUNCIL

United Kingdom

INSTITUTO DE MEDICINA MOLECULAR

Portugal

UNIVERSITY OF LEICESTER

United Kingdom

ADAM MICKIEWICZ UNIVERSITY IN POZNAN

Poland

UNIVERSITY OF AARHUS

Denmark

UNVERSIDAD DE BUENOS AIRES

Argentina

UNIVERSITÉ DE GENÈVE

Switzerland

UNIVERSITY OF DUNDEE

United Kingdom

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

THE HEBREW UNIVERSITY OF JERUSALEM

Israel

CENTRE EUROPÉEN DE RECHERCHE EN BIOLOGIE ET MÉDECINE - GROUPEMENT D'INTÉRÊT ECONOMIQUE

France

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

France

FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

Italy

SWISS INSTITUTE OF BIOINFORMATICS

Switzerland

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY

Poland

UNIVERSITAT POMPEU FABRA

Spain

UNIVERSITY OF SOUTHAMPTON

United Kingdom

Project information

Grant agreement ID: 518238

  • Start date

    1 January 2006

  • End date

    31 March 2011

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 32 130 000

  • EU contribution

    € 10 000 000

Coordinated by:

MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

Germany