Ankyrin-encoding genes in Wolbachia

Projektinformationen

ANKWOL

ID Finanzhilfevereinbarung: 25349

Startdatum 1 Januar 2006

Enddatum 31 Dezember 2007

Finanziert unter

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Gesamtkosten € 0,00

EU-Beitrag € 168 798,00

Koordiniert durch

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

Ziel

Wolbachia is an intracellular bacterium capable of inducing various forms of the reproductive manipulation in a diversity of arthropods. The best characterized type of reproductive manipulation is cytoplasmic incompatibility (CI) which makes sperm from inf ected males unable to complete fertilization of eggs from uninfected females whereas eggs from infected females develop normally. At present the molecular basis for CI is not understood. Several genomes of CI-inducing Wolbachia are being sequenced and one of the most striking features is the high number of genes encoding ankyrin repeat (ANK) containing proteins found. This protein motif is common in eukaryotes where it has been shown to mediate protein-protein interaction, to interact with the cytoskeleton, to act as a transcription factor and to modify the activity of cell-cycle regulating proteins. Since CI appears to involve disruption of host cell-cycle timing, the ANK genes represent promising candidates for control of the phenotype. The project aims to understand the role of the ANK genes in CI by looking at the variability and expression, potential interactions with other proteins and localization of the ankyrins in relevant tissues.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › proteomics
• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › biological sciences › microbiology › bacteriology
• natural sciences › biological sciences › zoology › invertebrate zoology
• natural sciences › biological sciences › genetics › genomes › prokaryotic genomes

Programm/Programme

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Thema/Themen

• MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF)

Aufforderung zur Vorschlagseinreichung

FP6-2004-MOBILITY-5
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

EIF - Marie Curie actions-Intra-European Fellowships

Koordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

• EU-Beitrag: Keine Daten
• Adresse: University Offices, Wellington Square ; OXFORD ; Vereinigtes Königreich
• Gesamtkosten: Keine Daten