Skip to main content
European Commission logo print header

Biomimetic surface modification of tissue engineering scaffolds with glycosaminoglycans

Cel

The replacement of bone and cartilage by tissue engineering is still hampered by the lack of degradable biomaterials that stimulate the growth and differentiation of cells. The layer-by-layer (LbL) technique has been identified as a useful tool to immobili se biogenic ligands maintaining their biological activity. It is an environmental safe, simple and cost efficient method to create material surfaces that are organised at the nanometer scale. LbL technique has been applied recently to coat the surface of biomedical materials using simple combinations of synthetic polyions and certain biological molecules. It is the aim of the project to apply the LbL technique for the biomimetic surface modification of polylactid acid (PLA) as a material approved for biome dical applications. The coating shall resemble main components the structure of the extracellular matrix (ECM) by using collagens and different glycosaminoglycans (GAG). The signalling capabilities of the ECM shall be mimicked by incorporation of adhesive proteins, such as fibronectin and growth factors. The binding of these molecules shall be achieved by their inclusion during the LbL process as well as their biospecific adsorption to the outermost layer of GAGs. The structure and properties of the LbL coa ting will be investigated by physicochemical methods. The biological activity will be studied with cultures of mesenchymal stem cells looking at cell growth and differentiation. Hence, the scientific focus of the project is on nanobiotechnologies and nanom etre scale engineering techniques which is a subtopic of the NMP priority. The project is also aimed to help the fellow to become an independent and experienced researcher by a number of training activities. This involves the participation in courses, the cooperation with experienced scientists to become trained in planning and management of research, to learn how to disseminate results within the scientific community and the public up to exploitations issues.

Zaproszenie do składania wniosków

FP6-2004-MOBILITY-7
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

MARTIN-LUTHER-UNIVERSITÄT HALLE WITTENBERG
Wkład UE
Brak danych
Adres
Universitätsplatz 1
HALLE (SAALE)
Niemcy

Zobacz na mapie

Linki
Koszt całkowity
Brak danych