genetic control of craniofacial development by hox cofactors Pbx1 and Pbx2

Projektinformationen

CRANIOFACIALGENETICS

ID Finanzhilfevereinbarung: 22003

Startdatum 1 Dezember 2005

Enddatum 30 November 2007

Finanziert unter

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Gesamtkosten € 0,00

EU-Beitrag € 257 923,00

Koordiniert durch

CENTRE EUROPéEN DE RECHERCHE EN BIOLOGIE ET MEDECINE-GROUPEMENT D'INTéRêT ECONOMIQUE
France

Ziel

"One third of all human congenital malformations affects craniofacial development and represents a serious concern for society. Within the developing primordia, unique spatio temporal patterns of gene expression correlate with cellular and tissue fates, id entities and behaviours and therefore, morphogenesis.The goal of this proposal is to finely dissect the genetic control of craniofacial development with particular focus on CNC (cranial neural crest cell) cell specification and craniofacial morphogenesis b y Hox homeodomain proteins and their cofactors Pbx1 and Pbx2, through the following specific aims:1) Genetically dissect the early roles of Pbx1 in craniofacial patterning and morphogenesis.To achieve this goal, I will generate knockout mice where Pbx1 is inactivated in a tissue-specific manner in neural crest and in discrete head structures, by utilizing the Pbx1 conditional knockout mouse recently generated in the Selleri laboratory and available Cre mice.2) Identify in vivo genetic interaction of Pbx1 wi th specific Hox genes known to pattern craniofacial structures, such as Hoxa2.In order to uncover possible synergistic interactions of Pbx1 and Hoxa2, responsible for BA2 craniofacial patterning, I will cross Pbx1 and Hoxa2 mutant mice. By doing so, I will attempt to genetically dissect Hox-dependent as well as independent Pbx1 functions that control the BA2 programs. The Hoxa2 mice are made available for these studies by Dr. Rijli (Strasbourg- France).3) Identify genetic interactions and/or overlapping fun ctions of Pbx1 with related family member Pbx2 in craniofacial development.In order to test the possible genetic interactions and overlapping functions between Pbx1 and Pbx2 in craniofacial development, I will analyze CNC derived craniofacial structures in Pbx1/Pbx2 double mutant mice."

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › medical biotechnology › cells technologies › stem cells

Schlüsselbegriffe

• branchial arches
• homeodomain proteins
• neural crest cells specification
• transcription factors

Programm/Programme

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Thema/Themen

• MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF)

Aufforderung zur Vorschlagseinreichung

FP6-2004-MOBILITY-6
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

OIF - Marie Curie actions-Outgoing International Fellowships

Koordinator

CENTRE EUROPéEN DE RECHERCHE EN BIOLOGIE ET MEDECINE-GROUPEMENT D'INTéRêT ECONOMIQUE

• EU-Beitrag: Keine Daten
• Adresse: 1 rue Laurent Fries, C U de Strasbourg ; B.P 10142 ILLKIRCH ; Frankreich
• Gesamtkosten: Keine Daten

Beteiligte (1)

WEILL MEDICAL COLLEGE CORNELL UNIVERSITY/SLOAN KETTERING INSTITUTE

Vereinigte Staaten

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• Adresse: 1300 York Avenue ; NEW YORK
• Gesamtkosten: Keine Daten