Using viral inhibitors to characterise signalling pathways involved in interferon induction

Projektinformationen

VIRAL IMMUNE EVASION

ID Finanzhilfevereinbarung: 23141

Startdatum 1 November 2005

Enddatum 31 Oktober 2007

Finanziert unter

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Gesamtkosten € 0,00

EU-Beitrag € 154 446,00

Koordiniert durch

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (HEREINAFTER CALLED TCD)
Ireland

Ziel

The innate immune system is the first line of defence against invading pathogens. The immediate response against viruses involves the secretion of interferon-alpha and -beta, which induce an `anti-viral state and apos; in the infected cell and warn neighbo uring cells of the danger. Double-stranded RNA (dsRNA), a hallmark of viral infection, is a potent stimulus of the interferon response, but the molecular mechanisms involved in dsRNA recognition and subsequent signal transduction have only partially been c haracterised. We aim to identify novel components of the signalling pathways involved in interferon induction, by exploiting the fact that many viruses are able to interfere with signalling pathways that regulate the innate immune response. Large DNA virus es possess a particularly ample repertoire of immuno-modulatory genes. We will screen the genome of vaccinia virus for inhibitors of the interferon response, and identify host proteins that interact with the viral inhibitors. The cellular targets of viral inhibition are likely to be key regulators of the anti-viral response, and we will attempt to characterise their function with respect to known signalling pathways. This project, while aimed at elucidating basic cellular signalling mechanisms, may yield re sults of great medical importance. A more detailed understanding of virus-host interactions is crucial at a time when (re-)emerging infectious diseases and the potential threat of biological warfare pose new scientific challenges. Also, the study of immuno -modulatory proteins may result in the identification of novel therapeutic targets for the treatment of chronic and acute inflammatory diseases. The proposed project would allow the candidate to enter a new field of study at the interface of molecular cell biology, immunology and virology. Due to the acquisition of new technical and transferable skills, the research training would be a crucial stepping stone in the candidate and apos;s academic career path.

Wissenschaftliches Gebiet

• medical and health sciences › health sciences › inflammatory diseases
• natural sciences › biological sciences › microbiology › virology
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › basic medicine › immunology
• medical and health sciences › health sciences › infectious diseases › DNA viruses

Schlüsselbegriffe

• innate immunity
• interferon
• signal transduction

Programm/Programme

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Thema/Themen

• MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF)

Aufforderung zur Vorschlagseinreichung

FP6-2004-MOBILITY-5
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

SCF - Marie Curie actions-Series of events

Koordinator

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (HEREINAFTER CALLED TCD)

• EU-Beitrag: Keine Daten
• Adresse: College Green ; DUBLIN 2 ; Irland
• Gesamtkosten: Keine Daten