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Synthesis and Assembly of Polymeric Nanotubes for Optical Biosensing

Synthesis and Assembly of Polymeric Nanotubes for Optical Biosensing

Objective

Nanotechnology involves the creation and utilization of materials and devices on the nanometer scale. In our days, biosensors are among the most promising nanotechnological achievements. They have emerged as reliable analytical tools in biomedicine, biolog y and environmental control. Recent developments of fabrication processes in the nanometer range by template based synthesis and deposition techniques have supplied new impetus to the concept of biosensor membranes. Methods for the production of individual parts with such small dimensions are quite readily available, but the controlled and efficient assembly of these parts into structures of higher order still remains a challenge. Besides, the production of a highly effective biosensor membrane requires not only miniaturization of the desired nanostructures into greater hierarchy, but also extreme care in the selection of correct functional groups and their optimum density.Based on the template synthesis technique, two different strategies to prepare well-or dered arrays of poly (gamma-Benzyl-L-Glutamate), PBLG polypeptide nanotubes as basis for optical biosensor applications are proposed here. By combining synthetic chemistry, photolithography for the assembly of nanotubes, and immobilization of biomolecules of special interest, well-ordered biosensor membranes with particular electro-optical properties should be obtained. Special emphasis is placed on the ability of PBLG biosensor membrane to quantify the amount of adsorbed biomolecules through the changes of the refractive index. The challenges and the architectural design strategies of the proposed research study are highlighted in detail. Additional emphasis is put on the characterization of the arrays of polypeptide nanotubes: electro-optical, structural a nd mechanical properties will be investigated. Finally, the quality of the two proposed techniques will be compared on the basis of the results of the aforementioned characterizations.

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Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Address

Hofgartenstrasse 8
Muenchen

Germany

Administrative Contact

Wolfgang KNOLL (Professor)

Project information

Grant agreement ID: 24731

  • Start date

    1 January 2006

  • End date

    31 December 2007

Funded under:

FP6-MOBILITY

Coordinated by:

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany