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Integrated highly sensitive fluorescence-based biosensor for diagnosis applications

Project information

Grant agreement ID: 16354

  • Start date

    1 August 2005

  • End date

    31 July 2008

Funded under:

FP6-NMP

  • Overall budget:

    € 2 607 285

  • EU contribution

    € 1 600 000

Coordinated by:

ATMEL-Grenoble SAS

France

Objective

Biochip technology allows assessing the expression of thousands of genes in parallel, opening the way to individualised healthcare. The INDIGO project will replace the current bulky and expensive technology used to hybridise and read fluorescent biochips by a lab-on-chip approach, with integrated signal processing and networking capacities. The project reconsiders the complete biochip user chain, and optimises each component in relation to others.

At the core of INDIGO is an innovative, miniature and highly sensitive, yet disposable fluorescence-based biosensor. It replaces the usual glass slide supporting the biological reaction by a sandwich of chemical and optical layers monolithically grafted on a CMOS or CCD image sensor. Intermediate layers play an essential optical role for guiding and filtering light. The upper side of the sensor is devoted to biology, the lower side to imaging by direct, and efficient light collection by the pixels. Improving signal level will enhance the sensitivity and robustness of the biological measurements.

Such a lensless imaging device produces images with new characteristics and needs development of new data processing software. The image produced by the sensor will be read in a laptop-connected readout head, and then filtered, segmented and measured; the results will be normalised, written in a standard format, ready to be recorded into a database or transmitted through networks.

With its user-friendly interface, the system will undergo clinical validation in biology labs, on samples from patients with different cancers and cardiovascular diseases. The INDIGO project is well suited to the joint IST and NMP call on biosensors for Diagnosis and Healthcare. On the NMP side, smart and hybrid materials like sol-gels with extreme characteristics, able to be industrially coated, as thin layers will be developed. On the IST side, new data treatment chain will give standardised biological data usable by the medical community at large.

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Coordinator

ATMEL-Grenoble SAS

Address

Avenue De Rochepleine
123 Saint Egreve

France

Participants (5)

ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS

France

Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali

Italy

FUNDACIÓN VALENCIANA DE INVESTIGACIONES BIOMÉDICAS

Spain

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III

Spain

GENEWAVE

France

Project information

Grant agreement ID: 16354

  • Start date

    1 August 2005

  • End date

    31 July 2008

Funded under:

FP6-NMP

  • Overall budget:

    € 2 607 285

  • EU contribution

    € 1 600 000

Coordinated by:

ATMEL-Grenoble SAS

France