Objective The main objective of this project is to develop a uniquely integrated DNA and protein detection system for medical diagnostics. Due to its ease of use and cost-effective nature, the system allows for fast as well as reliable DNA and protein testing. Aiming for point of care and doctor's office applications, e.g. early cancer recognition, this new testing system will improve public health. Moreover the project will enable a broad range of future applications in genomic risk analysis, individualized therapy and antibody detection for identification of diseases, resistances and allergies. Today bio-molecular detection is a promising technology for medical diagnosis with a high socio-economic impact.However, due to its complexity and costs, today's systems are restricted for use at specialized laboratories, making testing expensive and time-consuming. This projects aims to overcome these problems by providing a detection system based on direct electrical read-out, which can improve robustness and substantially decrease costs. This multi-analyte detection system includes novel integrated sensor disposables consisting of sensor arrays, on-chip CMOS read-out circuit, the biochemical sensor interfaces as well as suitable assays. By detection of mass changes at their surface, sensors work label-free according to key-lock principles.Recent progress in DNA and protein cancer marker testing will form the basis for the development of assays for the new system. An easy-to-use read-out setup will be developed, meeting requirements of robustness and usability. A clinical validation of the system in early diagnosis of breast cancer will demonstrate the enormous impact of this key technology for public health.The project will facilitate the entry of sensor array systems into the enormous in-vitro test market. It lays the foundation for strong scientific and economic collaboration between European companies and institutes, which will last long beyond the conclusion of the project. Fields of science medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologybreast cancermedical and health sciencesclinical medicineallergology Programme(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Topic(s) Data not available Call for proposal Data not available Funding Scheme STREP - Specific Targeted Research Project Coordinator SIEMENS AKTIENGESELLSCHAFT EU contribution No data Address WITTELSBACHERPLATZ 2 80333 MUENCHEN Germany See on map Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all BIOSENSOR APPLICATIONS SWEDEN AB Sweden EU contribution No data Address URSVIKSVÄGEN 131 A SUNDBYBERG See on map Total cost No data CRANFIELD UNIVERSITY United Kingdom EU contribution No data Address WHARLEY END CRANFIELD See on map Total cost No data Medizinische Universität Innsbruck Austria EU contribution No data Address Christoph-Probst Platz 1 INNSBRUCK See on map Total cost No data PERLOS OYJ Finland EU contribution No data Address Äyritie 12 C P.O. Box 178 VANTAA See on map Total cost No data UPPSALA UNIVERSITET Sweden EU contribution No data Address St Olofsgatan 10B 256 UPPSALA See on map Total cost No data VTT TECHNICAL RESEARCH CENTRE OF FINLAND Finland EU contribution No data Address VUORIMIEHENTIE 5 02044 VTT ESPOO See on map Total cost No data
